Intracellular calcium dysregulation in heart and brain diseases: Insights from induced pluripotent stem cell studies.

Zhang, Huayang; Ren, Xueming; Wu, Chunyu; He, Xinsen; Huang, Zhengxuan; Li, Yangpeng; Liao, Lei; Xiang, Jie; Li, Miaoling; Wu, Lin

Zhang, Huayang; Ren, Xueming; Wu, Chunyu; He, Xinsen; Huang, Zhengxuan; Li, Yangpeng; Liao, Lei; Xiang, Jie; Li, Miaoling; Wu, Lin.

Afiliación

Zhang H; Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Ren X; Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Wu C; Department of Ophthalmology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
He X; School of Clinical Medicine, Southwest Medical University, Luzhou, China.
Huang Z; Department of Gastroenterology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Li Y; Department of Neurosurgery, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Liao L; Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Xiang J; Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Li M; Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Wu L; Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.

J Neuropathol Exp Neurol ; 2024 Jul 13.

Article en En | MEDLINE | ID: mdl-39001792

ABSTRACT

ABSTRACT

The central nervous system (CNS) plays a role in regulating heart rate and myocardial contractility through sympathetic and parasympathetic nerves, and the heart can impact the functional equilibrium of the CNS through feedback signals. Although heart and brain diseases often coexist and mutually influence each other, the potential links between heart and brain diseases remain unclear due to a lack of reliable models of these relationships. Induced pluripotent stem cells (iPSCs), which can differentiate into multiple functional cell types, stem cell biology and regenerative medicine may offer tools to clarify the mechanisms of these relationships and facilitate screening of effective therapeutic agents. Because calcium ions play essential roles in regulating both the cardiovascular and nervous systems, this review addresses how recent iPSC disease models reveal how dysregulation of intracellular calcium might be a common pathological factor underlying the relationships between heart and brain diseases.

Palabras clave

brain disease; heart disease; induced pluripotent stem cells; intracellular calcium dysregulation

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