Bisphenol A: Epigenetic effects on the male reproductive system and male offspring.
Reprod Toxicol
; 129: 108656, 2024 10.
Article
en En
| MEDLINE
| ID: mdl-39004383
ABSTRACT
Bisphenol A (BPA) is a commonly used organic compound. Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in epigenetic markers can adversely affect reproductive function. Furthermore, these changes in epigenetic markers can be transmitted to offspring through the father. Here, we review the effects of BPA exposure on various epigenetic markers in the male reproductive system, including DNA methylation, histone modifications, and noncoding RNA, as well as associated changes in the male reproductive function. We also reviewed the effects of father's exposure to BPA on offspring epigenetic modification patterns.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fenoles
/
Compuestos de Bencidrilo
/
Metilación de ADN
/
Epigénesis Genética
/
Disruptores Endocrinos
/
Genitales Masculinos
Idioma:
En
Revista:
Reprod Toxicol
Asunto de la revista:
EMBRIOLOGIA
/
MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Año:
2024
Tipo del documento:
Article