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Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy.
Zhang, Linhao; He, Maomao; Xia, Xiang; Ma, Zhiyuan; Lv, Chengyuan; Wang, Ran; Liu, Wenkai; Fan, Jiangli; Peng, Xiaojun; Sun, Wen.
Afiliación
  • Zhang L; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • He M; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Xia X; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Ma Z; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Lv C; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Wang R; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Liu W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Fan J; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Peng X; Ningbo Institute of Dalian University of Technology, Ningbo 315016, China.
  • Sun W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
Chem Commun (Camb) ; 60(63): 8248-8251, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-39011721
ABSTRACT
This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes / Microambiente Tumoral / Imagen Óptica / Ferroptosis Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes / Microambiente Tumoral / Imagen Óptica / Ferroptosis Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article