Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China.

Tian, Shen; Wu, Xingyong; Liu, Lin; Li, Anyang; Li, Xuemiao; Pei, Hua; Wang, Yanshuang; Dance, David A B; Chen, Hai; Xia, Qianfeng

Tian, Shen; Wu, Xingyong; Liu, Lin; Li, Anyang; Li, Xuemiao; Pei, Hua; Wang, Yanshuang; Dance, David A B; Chen, Hai; Xia, Qianfeng.

Afiliación

Tian S; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Wu X; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Liu L; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Li A; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Li X; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Pei H; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Wang Y; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
Dance DAB; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Lao Democratic People's Republic; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropica
Chen H; Department of Clinical Laboratory, People's Hospital of Sanya, Sanya, Hainan, China.
Xia Q; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China. Electronic address: xiaqianfeng@haimnc.edu.cn.

Drug Resist Updat ; 76: 101121, 2024 Sep.

Article en En | MEDLINE | ID: mdl-39018660

ABSTRACT

ABSTRACT

In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.

Asunto(s)

Antibacterianos; Burkholderia pseudomallei; Ceftazidima; Farmacorresistencia Bacteriana; Melioidosis; Pruebas de Sensibilidad Microbiana; Mutación Puntual; Burkholderia pseudomallei/genética; Burkholderia pseudomallei/efectos de los fármacos; Ceftazidima/farmacología; Humanos; China; Antibacterianos/farmacología; Melioidosis/microbiología; Melioidosis/tratamiento farmacológico; Farmacorresistencia Bacteriana/genética; Proteínas Bacterianas/genética; Alelos

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Ceftazidima / Burkholderia pseudomallei / Mutación Puntual / Farmacorresistencia Bacteriana / Melioidosis / Antibacterianos País/Región como asunto: Asia Idioma: En Revista: Drug Resist Updat Asunto de la revista: ANTINEOPLASICOS Año: 2024 Tipo del documento: Article

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