Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.
Mol Metab
; 87: 101992, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39019114
ABSTRACT
OBJECTIVES:
We here assessed whether typical pathogens of laboratory mice affect the development of diet-induced obesity and glucose intolerance, and whether colonization affects the efficacy of the GLP-1R agonist liraglutide and of the GLP-1/GIP co-agonist MAR709 to treat obesity and diabetes.METHODS:
Male C57BL/6J mice were experimentally infected with Helicobacter hepaticus, Rodentibacter pneumotropicus and Staphylococcus aureus and compared to a group of uninfected specific and opportunistic pathogen free (SOPF) mice. The development of diet-induced obesity and glucose intolerance was monitored over a period of 26 weeks. To study the influence of pathogens on drug treatment, mice were then subjected for 6 days daily treatment with either the GLP-1 receptor agonist liraglutide or the GLP-1/GIP co-agonist MAR709.RESULTS:
Colonized mice did not differ from SOPF controls regarding HFD-induced body weight gain, food intake, body composition, glycemic control, or responsiveness to treatment with liraglutide or the GLP-1/GIP co-agonist MAR709.CONCLUSIONS:
We conclude that the occurrence of H. hepaticus, R. pneumotropicus and S. aureus does neither affect the development of diet-induced obesity or type 2 diabetes, nor the efficacy of GLP-1-based drugs to decrease body weight and to improve glucose control in mice.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
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Intolerancia a la Glucosa
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Incretinas
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Dieta Alta en Grasa
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Liraglutida
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Ratones Endogámicos C57BL
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Obesidad
Idioma:
En
Revista:
Mol Metab
Año:
2024
Tipo del documento:
Article