Effect of Specific mode electroacupuncture stimulation combined with NGF during the ischaemic stroke: Study protocol for a randomized controlled trial.
Clinics (Sao Paulo)
; 79: 100451, 2024.
Article
en En
| MEDLINE
| ID: mdl-39033586
ABSTRACT
BACKGROUND:
The emergence of the Nerve Growth Factor (NGF) has promoted the development of neuroprotective therapy; however, it has little effect on cerebral ischemia because of its poor Blood-Brain Barrier (BBB) permeability. Specific Mode Electroacupuncture Stimulation (SMES) can open BBB safely and effectively; however, it has shown inconclusive clinical effects and indirect clinical evidence in the recovery phase. Hence, the authors conducted a multicentre, randomized, placebo-controlled, assessor-blinded clinical trial to assess the effectiveness and safety of SMES combined with NGF treatment used during ischaemic stroke recovery.METHODS:
A total of 288 stroke patients from three hospitals will be recruited and randomly allocated to four groups acupuncture + placebo, acupuncture + NGF, SMES + placebo, and SMES + NGF, in a 1111 ratio. Assessment data will be collected at baseline, 2-weeks, and 4-weeks during the treatment period, as well as at the 4-week and 8-week follow-up after treatment completion. The primary outcome measure will be the basic cure rate. The secondary outcome measures include the simplified Modified Barthel Index, Timed Up and Go Test, Fugl-Meyer Assessment of Motor Function Score, Tinetti Performance Oriented Mobility Assessment, Montreal Cognitive Assessment, and Loewenstein Occupational Therapy Cognitive Assessment. Moreover, resting-state functional magnetic resonance imaging and Functional near-infrared spectroscopy can detect changes in cerebral blood flow and brain function and investigate the relationship between the clinical efficacy and mechanism of the prescribed interventions.CONCLUSION:
This study will provide clinical evidence for the efficacy and safety of SMES combined with NGF in the treatment of stroke patients.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Electroacupuntura
/
Factor de Crecimiento Nervioso
/
Accidente Cerebrovascular Isquémico
Idioma:
En
Revista:
Clinics (Sao Paulo)
Asunto de la revista:
MEDICINA
Año:
2024
Tipo del documento:
Article