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Current profile of phenotypic pyrethroid resistance in Rhipicephalus microplus (Acari: Ixodidae) populations sampled from Marathwada region of Maharashtra state, India.
Khating, Sandip; Jadhav, Nitin; Vijay, M; Sharma, Anil Kumar; Srivastava, Anand; Jadhao, Suresh; Kumar, Sachin; Kalwaghe, Shrikant; Siddiqui, M F M F; Narawade, Mahima; Dhabale, Ankush; Chigure, Gajanan.
Afiliación
  • Khating S; Department of Veterinary Parasitology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Jadhav N; Department of Veterinary Pharmacology & Toxicology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Vijay M; DBT-National Institute of Animal Biotechnology, Hyderabad, 500032, Telangana, India.
  • Sharma AK; School of Agriculture, Uttaranchal University, Dehradun, 248007, Uttarakhand, India.
  • Srivastava A; DBT-National Institute of Animal Biotechnology, Hyderabad, 500032, Telangana, India.
  • Jadhao S; Department of Veterinary Parasitology, Nagpur Veterinary College, MAFSU, Nagpur, Maharashtra, India.
  • Kumar S; Department of Zoology, Constituent Government College (MJP Rohilkhand University, Bareilly), Meerapur Bangar, Bijnor, 246723, Uttar Pradesh, India.
  • Kalwaghe S; Department of Veterinary Parasitology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Siddiqui MFMF; Department of Veterinary Medicine, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Narawade M; Department of Veterinary Parasitology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Dhabale A; Department of Veterinary Parasitology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India.
  • Chigure G; Department of Veterinary Parasitology, College of Veterinary & Animal Sciences, MAFSU, Parbhani, Maharashtra, India. gajananchigure@mafsu.in.
Parasitol Res ; 123(7): 282, 2024 Jul 22.
Article en En | MEDLINE | ID: mdl-39037590
ABSTRACT
This study examined the pattern of resistance to widely applied synthetic pyrethroids, i.e., cypermethrin and deltamethrin, against larvae of Rhipicephalus microplus ticks sampled from Marathwada region in Maharashtra, India. The study also examined the role of α- and ß-esterases and glutathione-S-transferase (GST) in resistance development. All eight R. microplus isolates tested were resistant to deltamethrin (RL IV), having RR50 values from 6.88 to 131.26. LPT analysis exhibited the resistance level II deltamethrin resistance in Beed and Hingoli, III in Dharashiv, and IV in Sambhajinagar, Parbhani, Latur, Jalna, and Nanded isolates. The LIT analysis showed that Dharashiv field isolates had the lowest LC50 value of 229.09 ppm against cypermethrin, while Sambhajinagar field isolates had the highest at 489.78 ppm. The RR50 ranged from 1145.45 to 2448.9. Seven isolates were level I resistant to cypermethrin while the Jalna isolate was level II resistant. In larvae treated with deltamethrin and cypermethrin, the activity of α- and ß-esterase enzymes increased significantly compared to control groups. The enzyme ratios in treated larvae ranged from 0.7533 to 1.7023 for α-esterase and 0.7434 to 3.2054 for ß-esterase. The Hingoli isolate treated with cypermethrin exhibited the highest α-esterase activity (903.261), whereas Sambhajinagar isolate had the highest GST enzyme ratio (2.8224) after deltamethrin exposure. When exposed to cypermethrin, the Hingoli isolate showed the highest GST enzyme ratio, 2.0832. The present study provides the current resistance status in tick populations from Marathwada region indicating deltamethrin and cypermethrin to be ineffective for tick control. The results also suggest that SP compounds should be regulated in this region and alternative control strategies should be introduced.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piretrinas / Rhipicephalus / Acaricidas / Glutatión Transferasa / Larva / Nitrilos País/Región como asunto: Asia Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piretrinas / Rhipicephalus / Acaricidas / Glutatión Transferasa / Larva / Nitrilos País/Región como asunto: Asia Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article