The scheduling of adolescence with Netrin-1 and UNC5C.
Elife
; 122024 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-39056276
ABSTRACT
Dopamine axons are the only axons known to grow during adolescence. Here, using rodent models, we examined how two proteins, Netrin-1 and its receptor, UNC5C, guide dopamine axons toward the prefrontal cortex and shape behaviour. We demonstrate in mice (Mus musculus) that dopamine axons reach the cortex through a transient gradient of Netrin-1-expressing cells - disrupting this gradient reroutes axons away from their target. Using a seasonal model (Siberian hamsters; Phodopus sungorus) we find that mesocortical dopamine development can be regulated by a natural environmental cue (daylength) in a sexually dimorphic manner - delayed in males, but advanced in females. The timings of dopamine axon growth and UNC5C expression are always phase-locked. Adolescence is an ill-defined, transitional period; we pinpoint neurodevelopmental markers underlying this period.
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1
Base de datos:
MEDLINE
Asunto principal:
Netrina-1
/
Receptores de Netrina
Idioma:
En
Revista:
Elife
Año:
2024
Tipo del documento:
Article