Gaining a new angle on pancreas cancer: A pre-operative thrombelastographic parameter predicts recurrence and survival among patients with resected periampullary and pancreatic adenocarcinoma.
Am J Surg
; 238: 115820, 2024 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-39059340
ABSTRACT
BACKGROUND:
It has previously been demonstrated that Thrombelastography(TEG) angle may be associated with recurrence and survival in pancreas cancer in a cohort of patients operated on at the University of Colorado in 2016-2017. Now approaching 10 years of follow-up, we revisit these associations and strengthen these claims with multivariate analysis.METHODS:
Retrospective chart review was performed. Statistical analysis was conducted using STATA. Receiver operating characteristic(ROC) curves identified the performance of angle for predicting recurrence&survival. Unadjusted and adjusted cox regression models were used to identify significant predictors of these outcomes.RESULTS:
47 patients were included with median follow-up of 29.6 months. ROC curves for angle predicting recurrence and survival identified a cutoff of 44.5°. KM curves demonstrated that patients above the cutoff were more likely to recur(90%vs46 â%,p â= â0.001) and less likely to survive(16%vs56 â%,p â= â0.001). Angle remained significant on multivariate analyses (HR recurrence3.64[1.32-10.25],HR survival3.80[1.38-10.46]).CONCLUSIONS:
TEG angle is independently associated with disease recurrence and overall survival in pancreas cancer. This may be identifying virulent tumor biology, but further studies are required. A prospective study is underway.
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Base de datos:
MEDLINE
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En
Revista:
Am J Surg
/
Am. j. surg
/
American journal of surgery
Año:
2024
Tipo del documento:
Article