Loss of ARID1A 'loops' in STING.
Trends Immunol
; 45(8): 568-570, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39060141
ABSTRACT
In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas de Unión al ADN
/
Proteínas de la Membrana
/
Neoplasias
Idioma:
En
Revista:
Trends Immunol
/
Trends immunol
/
Trends in immunology
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article