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Rational Design of Pectin-Chitosan Polyelectrolyte Nanoparticles for Enhanced Temozolomide Delivery in Brain Tumor Therapy.
Silant'ev, Vladimir E; Belousov, Andrei S; Trukhin, Fedor O; Struppul, Nadezhda E; Shmelev, Mikhail E; Patlay, Aleksandra A; Shatilov, Roman A; Kumeiko, Vadim V.
Afiliación
  • Silant'ev VE; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
  • Belousov AS; Laboratory of Electrochemical Processes, Institute of Chemistry, Far Eastern Branch of Russian Academy of Sciences, Vladivostok 690022, Russia.
  • Trukhin FO; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
  • Struppul NE; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
  • Shmelev ME; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
  • Patlay AA; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
  • Shatilov RA; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch of Russian Academy of Sciences, Vladivostok 690041, Russia.
  • Kumeiko VV; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690922, Russia.
Biomedicines ; 12(7)2024 Jun 23.
Article en En | MEDLINE | ID: mdl-39061967
ABSTRACT
Conventional chemotherapeutic approaches currently used for brain tumor treatment have low efficiency in targeted drug delivery and often have non-target toxicity. Development of stable and effective drug delivery vehicles for the most incurable diseases is one of the urgent biomedical challenges. We have developed polymer nanoparticles (NPs) with improved temozolomide (TMZ) delivery for promising brain tumor therapy, performing a rational design of polyelectrolyte complexes of oppositely charged polysaccharides of cationic chitosan and anionic pectin. The NPs' diameter (30 to 330 nm) and zeta-potential (-29 to 73 mV) varied according to the initial mass ratios of the biopolymers. The evaluation of nanomechanical parameters of native NPs demonstrated changes in Young's modulus from 58 to 234 kPa and adhesion from -0.3 to -3.57 pN. Possible mechanisms of NPs' formation preliminary based on ionic interactions between ionogenic functional groups were proposed by IR spectroscopy and dynamic rheology. The study of the parameters and kinetics of TMZ sorption made it possible to identify compounds that most effectively immobilize and release the active substance in model liquids that simulate the internal environment of the body. A polyelectrolyte carrier based on an equal ratio of pectin-chitosan (0.1% by weight) was selected as the most effective for the delivery of TMZ among a series of obtained NPs, which indicates a promising approach to the treatment of brain tumors.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article