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Combinations of Antibiotics Effective against Extensively- and Pandrug-Resistant Acinetobacter baumannii Patient Isolates.
Halim, Justin; Carr, Rachel A; Fliorent, Rebecca; Jonnalagadda, Keertana; Kurbonnazarova, Maftuna; Kaur, Muskanjot; Millstein, Ian; Carabetta, Valerie J.
Afiliación
  • Halim J; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
  • Carr RA; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
  • Fliorent R; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA.
  • Jonnalagadda K; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA.
  • Kurbonnazarova M; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA.
  • Kaur M; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA.
  • Millstein I; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
  • Carabetta VJ; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Microorganisms ; 12(7)2024 Jul 02.
Article en En | MEDLINE | ID: mdl-39065123
ABSTRACT
Infections due to drug-resistant Acinetobacter baumannii strains are increasing and cause significant morbidity and mortality, especially in hospitalized and critically ill patients. A. baumannii rapidly develops resistance to numerous antibiotics, and antibiotics traditionally used against this deadly pathogen have been failing in recent years, highlighting the need to identify new treatment strategies. Treatment options that have shown promise include revisiting common antibiotics not typically used against A. baumannii, evaluating new antibiotics recently introduced to market, and identifying combinations of antibiotics that display synergistic interactions. In this study, we characterized the antibiotic susceptibility profiles of extensively (XDR) and pandrug-resistant (PDR) A. baumannii patient isolates. We examined the potency of 22 standard-of-care antibiotics and the newer antibiotics eravacycline, omadacycline, and plazomicin against these strains. Furthermore, we examined combinations of these antibiotics against our collection to identify synergistic effects. We found that this collection is highly resistant to most or all standard-of-care antibiotics, except for minocycline and rifampin. We show that eravacycline and omadacycline are effective against these strains based on minimum inhibitory concentrations. We also identified two highly effective combinations, cefepime and amikacin and cefepime and ampicillin-sulbactam, which exhibited high rates of synergy against this collection. This information is valuable in our battle against highly drug resistant and virtually untreatable A. baumannii infections.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Microorganisms Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Microorganisms Año: 2024 Tipo del documento: Article