Angio-microRNAs in diabetic foot ulcer-: Mechanistic insights and clinical perspectives.
Prog Biophys Mol Biol
; 192: 1-10, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39069213
ABSTRACT
Diabetic foot ulcers, as one of the chronic wounds, are a serious challenge in the global healthcare system which have shown notable growth in recent years. DFU is associated with impairment in various stages of wound healing, including angiogenesis. Aberrant expression of microRNAs (miRNAs) involved in the disruption of the balance between angiogenic and anti-angiogenic factors, plays a crucial role in angiogenesis dysfunction. Alteration in the expression of angiomiRNAs (angiomiRs) have the potential to function as biomarkers in chronic wounds. Additionally, considering the rising importance of therapeutic RNAs, there is potential for utilizing angiomiRs in wound healing to induce angiogenesis. This review aims to explore angiogenesis in chronic wounds and investigate the mechanisms mediated by pro- and anti-angiomiRs in the context of diabetic foot ulcers.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
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Pie Diabético
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MicroARNs
Idioma:
En
Revista:
Prog Biophys Mol Biol
Año:
2024
Tipo del documento:
Article