Predictive value of serum MED1 and PGC-1α for bronchopulmonary dysplasia in preterm infants.
BMC Pulm Med
; 24(1): 363, 2024 Jul 28.
Article
en En
| MEDLINE
| ID: mdl-39069619
ABSTRACT
OBJECTIVE:
This study aimed to predict the bronchopulmonary dysplasia (BPD) in preterm infants with a gestational age(GA) < 32 weeks utilizing clinical data, serum mediator complex subunit 1 (MED1), and serum peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α).METHODS:
This prospective observational study enrolled 70 preterm infants with GA < 32 weeks. The infants were categorized into two groups non-BPD group(N = 35) and BPD group(N = 35), including 25 cases with mild BPD and 10 patients with moderate/severe subgroups. We performed multifactorial regression analysis to investigate the postnatal risk factors for BPD. Furthermore, we compared serum levels of biomarkers, including MED1 and PGC-1α, among infants with and without BPD at postnatal days 1, 7, 14, 28, and PMA 36 weeks. A logistic regression model was constructed to predict BPD's likelihood using clinical risk factors and serum biomarkers.RESULTS:
Serum levels of MED1 on the first postnatal day, PGC-1α on the 1st, 7th, and 28th days, and PMA at 36 weeks were significantly lower in the BPD group than in the non-BPD group (P < 0.05). Furthermore, the predictive model for BPD was created by combing serum levels of MED1 and PGC-1α on postnatal day 1 along with clinical risk factors such as frequent apnea, mechanical ventilation time > 7 d, and time to reach total enteral nutrition. Our predictive model had a high predictive accuracy(C statistics of 0.989) .CONCLUSION:
MED1and PGC-1α could potentially serve as valuable biomarkers, combined with clinical factors, to aid clinicians in the early diagnosis of BPD.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Displasia Broncopulmonar
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Recien Nacido Prematuro
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Biomarcadores
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Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma
Idioma:
En
Revista:
BMC Pulm Med
Año:
2024
Tipo del documento:
Article