Tryptase in drug-induced anaphylaxis: the need for acute and baseline values.
Curr Opin Allergy Clin Immunol
; 24(5): 293-299, 2024 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-39079161
ABSTRACT
PURPOSE OF REVIEW The purpose of this narrative review was to summarize data and official recommendations purporting to paired tryptase determination in patients experiencing drug-induced anaphylaxis, published between January 1, 2023 and June 1, 2024. RECENT FINDINGS:
Three main lines of evidence obtained through paired acute and baseline tryptase determination were identified diagnostic criterion for hypersensitivity reactions involving systemic mast cell activation; differential diagnostic criterion for hypersensitivity reactions involving other mechanisms of immediate reactions; and added value of acute and baseline tryptase levels for personalized management following drug-induced anaphylaxis cause, risk of recurrence, underlying mast cell conditions including hereditary α-tryptasemia, familial clusters.SUMMARY:
The implementation of existing guidelines which consensually recommend paired tryptase measurement is a persistent unmet need hampering optimal diagnosis of drug-induced anaphylaxis and patient management. Another major unmet need is the lack of standardized recommendations for hereditary α-tryptasemia testing and counselling. Progress in this field is seen at a rapid pace, requiring significant efforts of continued medical education for practicing clinicians and laboratory specialists worldwide.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hipersensibilidad a las Drogas
/
Triptasas
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Anafilaxia
Idioma:
En
Revista:
Curr Opin Allergy Clin Immunol
/
Curr. opin. allergy clin. immunol
/
Current opinion in allergy and clinical immunology
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article