Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.

Zozulya, S A; Akopyan, A A; Tenditnik, M V; Ovsyukova, M V; Korolenko, T A; Klyushnik, T P; Tikhonova, M A; Pupyshev, A B

Zozulya, S A; Akopyan, A A; Tenditnik, M V; Ovsyukova, M V; Korolenko, T A; Klyushnik, T P; Tikhonova, M A; Pupyshev, A B.

Afiliación

Zozulya SA; Mental Health Research Center, Moscow, Russia. s.ermakova@mail.ru.
Akopyan AA; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Tenditnik MV; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Ovsyukova MV; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Korolenko TA; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Klyushnik TP; Mental Health Research Center, Moscow, Russia.
Tikhonova MA; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Pupyshev AB; Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.

Bull Exp Biol Med ; 177(2): 207-211, 2024 Jun.

Article en En | MEDLINE | ID: mdl-39090471

ABSTRACT

ABSTRACT

In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.

Asunto(s)

Enfermedad de Alzheimer; Modelos Animales de Enfermedad; Microglía; Trehalosa; Animales; Trehalosa/farmacología; Trehalosa/uso terapéutico; Enfermedad de Alzheimer/tratamiento farmacológico; Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/patología; Microglía/efectos de los fármacos; Microglía/metabolismo; Ratones; Proteínas de Microfilamentos/metabolismo; Inflamación/tratamiento farmacológico; Inflamación/metabolismo; Masculino; Proteínas de Unión al Calcio/metabolismo; Elastasa de Leucocito/metabolismo; Neutrófilos/efectos de los fármacos; Neutrófilos/metabolismo; Disacáridos/farmacología; Antiinflamatorios/farmacología

Palabras clave

Alzheimer's disease; experimental model; leukocyte elastase; microglia; trehalose

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trehalosa / Microglía / Modelos Animales de Enfermedad / Enfermedad de Alzheimer Idioma: En Revista: Bull Exp Biol Med / Bull. exp. biol. med / Bulletin of experimental biology and medicine Año: 2024 Tipo del documento: Article

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