Clinical features and prognosis of patients with anti-GBM disease combined with mesangial IgA deposition.
Front Immunol
; 15: 1373581, 2024.
Article
en En
| MEDLINE
| ID: mdl-39104528
ABSTRACT
Introduction:
Anti-GBM diseases with IgA deposition in the mesangial region are rarely described.The factors influencing renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition are unknown.Methods:
We searched the pathological reports of the First Affiliated Hospital of Zhengzhou University from 2015 to 2023 and found that a total of 72 patients with the anti-GBM disease and 25 patients combined with mesangial IgA deposition. We studied the clinical and pathological features, renal prognosis, and the factors affecting renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition.Results:
Their median age was 44 years, and their age distribution was unimodal. The proportion of oliguria or anuria in patients with anti-GBM disease combined with mesangial IgA deposition was significantly lower than that in patients with classic anti-GBM disease (13.04 vs. 42.31%, p=0.030). Their 24-hour urinary protein excretion was significantly higher [median3.25 vs. 1.12g/24h, Interquartile range(IQR)1.032~3.945 vs. 0.63~1.79g/24h, p=0.020], serum creatinine (SCr) level at the initial diagnosis was lower(median456.0 vs. 825.5µmol/L, IQR270.0~702.0 vs. 515.8~1231.2µmol/L, p=0.002), peak SCr level was lower (median 601.0 vs. 907.2µmol/L, IQR 376.5~937.0 vs. 607.0~1361.2µmol/L, p=0.007), and their serum complement 3(C3) level was higher(median 1.275 vs. 1.015g/L, IQR1.097~1.462 vs. 0.850~1.220g/L, p=0.027). They had better renal outcomes during follow-up (p<0.001). After adjustment for hypertension, oliguria or anuria, and crescents%, IgA deposition in the mesangial region was still an independent protective factor (p=0.003) for ESRD in anti-GBM patients. Hypertension (p=0.026) and SCr levels at initial diagnosis (p=0.004) were risk factors for renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition.Discussion:
Patients with anti-GBM disease combined with mesangial IgA deposition have less severe renal impairment and better renal prognosis than patients with classic anti-GBM disease.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina A
Idioma:
En
Revista:
Front Immunol
Año:
2024
Tipo del documento:
Article