The Role of Short-Chain Fatty Acids in Myocardial Ischemia-Reperfusion Injury.
Curr Nutr Rep
; 13(4): 701-708, 2024 Dec.
Article
en En
| MEDLINE
| ID: mdl-39110372
ABSTRACT
PURPOSE OF REVIEW This study aims to review the effects of short-chain fatty acids (SCFAs) in regulating the myocardial ischemia-reperfusion injury (MIRI). RECENT FINDINGS:
Coronary heart disease (CHD) is a well-known leading cause of death and disability worldwide. Cardiac substrate metabolism plays the determinant role in assessing the severity of heart injury due to the abruptly shifted energy production during the MIRI. Fatty acids are the main energy fuels for the heart, which are classified into long-, medium- and short chain fatty acids by the length of carbon chain. SCFAs are the main metabolites derived from the anaerobic bacterial fermentation of fiber-rich diets, which are shown to play a protective role in cerebrovascular disease previously. Meanwhile, accumulating evidences suggest that SCFAs can also play a crucial role in cardiac energy metabolism. Results of various studies revealed the cardioprotective effects of SCFAs by displaying anti-inflammatory and anti-ferroptotic function, connecting gut-brain neural circuit and regulating the intestinal flora.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión Miocárdica
/
Metabolismo Energético
/
Ácidos Grasos Volátiles
Idioma:
En
Revista:
Curr Nutr Rep
Año:
2024
Tipo del documento:
Article