Genetic Features of Tongue Cancer Recurrence in Young Adults.
Bull Exp Biol Med
; 177(3): 359-362, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-39127975
ABSTRACT
To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Lengua
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Proteína p53 Supresora de Tumor
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Secuenciación del Exoma
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Recurrencia Local de Neoplasia
Idioma:
En
Revista:
Bull Exp Biol Med
/
Bull. exp. biol. med
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Bulletin of experimental biology and medicine
Año:
2024
Tipo del documento:
Article