Near-infrared light-enhanced colorimetric signal amplification strategy for tumor marker detection based on MoS2/CuO/Au nanocomposite.
Mikrochim Acta
; 191(9): 555, 2024 08 22.
Article
en En
| MEDLINE
| ID: mdl-39172272
ABSTRACT
A novel signal amplification strategy was developed by combining near-infrared light with MoS2/CuO/Au nanocomposite for building a colorimetric immunoassay. First, MoS2/CuO/Au nanocomposite was synthesized by precipitation and photoreduction methods and characterized by scanning electron microscopy (SEM) and X-ray powder diffraction (XRD). MoS2/CuO/Au nanocomposite has oxidase-like activity and can oxidize TMB to form a blue product (TMBox). Further, the catalytic oxidation of TMB was accelerated under near-infrared (NIR) laser radiation. The sandwich-type colorimetric immunoassay was constructed using MoS2/CuO/Au nanocomposite. Under the enhancement of near-infrared light, carcinoembryonic antigen (CEA) was sensitively detected in the range 0.1 to 40 ng/mL with the limit of detection of 0.03 ng/mL. Moreover, the immunosensor has excellent selectivity and anti-interference, good repeatability, and stability.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Antígeno Carcinoembrionario
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Biomarcadores de Tumor
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Colorimetría
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Cobre
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Disulfuros
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Nanocompuestos
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Límite de Detección
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Oro
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Rayos Infrarrojos
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Molibdeno
Idioma:
En
Revista:
Mikrochim Acta
Año:
2024
Tipo del documento:
Article