Advances in spatial multi-omics in tumors.
Tumori
; 110(5): 327-339, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39185632
ABSTRACT
Single-cell techniques have convincingly demonstrated that tumor tissue usually contains multiple genetically defined cell subclones with different gene mutation sets as well as various transcriptional profiles, but the spatial heterogeneity of the microenvironment and the macrobiological characteristics of the tumor ecosystem have not been described. For the past few years, spatial multi-omics technologies have revealed the cellular interactions, microenvironment, and even systemic tumor-host interactions in the tumor ecosystem at the spatial level, which can not only improve classical therapies such as surgery, radiotherapy, and chemotherapy but also promote the development of emerging targeted therapies in immunotherapy. Here, we review some emerging spatial omics techniques in cancer research and therapeutic applications and propose prospects for their future development.
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Base de datos:
MEDLINE
Asunto principal:
Genómica
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Microambiente Tumoral
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Neoplasias
Idioma:
En
Revista:
Tumori
Año:
2024
Tipo del documento:
Article