NCS-Mediated Direct C(sp3)-H Oxygenation of 2-Methylindoles Using Water as the Oxygen Source.
J Org Chem
; 2024 Sep 19.
Article
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| MEDLINE
| ID: mdl-39298672
ABSTRACT
In continuation of our research interest in the green oxidation of indoles, we further explore the direct oxidation of 2-methylindoles to 2-formyl indoles promoted by NCS and associated with H2O as the oxygen source. This methodology was demonstrated to be a robust protocol consisting of chlorination, SN2', and oxidation processes, and presents a reasonably broad substrate scope and excellent functional group tolerance, thus enabling the preparation of high added-value versatile building blocks susceptible to further functionalization.
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MEDLINE
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En
Revista:
J Org Chem
Año:
2024
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Article