Alginate-modified ZnO anti-planktonic and anti-biofilm nanoparticles for infected wound healing.
Int J Biol Macromol
; : 135739, 2024 Sep 17.
Article
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| MEDLINE
| ID: mdl-39299433
ABSTRACT
Bacterial infections is one of the main factors delaying the wound healing, which has become a serious challenge for healthcare systems. Zinc oxide nanoparticles (ZnO NPs), which show broad-spectrum and excellent antibacterial activity, tend to aggregate easily and therefore hardly penetrate into bacterial biofilms, showing limited anti-biofilm properties. Hereinï¼alginate (ALG) modified ZnO NPs (ZnO@ALG) were prepared via the combination of mussel-inspired method and "thiol-Michael" click reaction, which showed excellent dispersion and biocompatibility. Besides, the interactions between ZnO@ALG and bacteria was much better than that of ZnO NPs, and makes the bacteria produced more reactive oxygen species (ROS) than bare ZnO NPs. The anti-planktonic activity of ZnO@ALG (250⯵g/mL) could reach almost 100â¯%, which was 2-3 times higher than that of bare ZnO NPs. In addition, the ZnO@ALG could significantly accelerate the healing of S. aureus infected wounds, and the wound healing rate of ZnO@ALG group was about 79.2â¯%, which was significantly higher than that of ZnO NPs (~65.8â¯%). This study demonstrates that the ZnO@ALG holds a great potential in the anti-planktonic and anti-biofilm fields, and the ALG-modification method can be an effective strategy to enhance the antibacterial properties of nanomaterials.
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MEDLINE
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Int J Biol Macromol
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2024
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Article