Recombinant A17 Lys human insulin: purification and characterization.
Biochem Mol Biol Int
; 36(5): 1079-85, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7581003
ABSTRACT
Recombinant A17 Lys human insulin precursor expressed in yeast cells was isolated from the culture medium. After purification, the precursor was converted into A17 Lys human insulin. A17 Lys human insulin can be crystallized but has much lower receptor-binding and biological activities than porcine or human insulin where A17 is Glu. It is proposed that the A17 Glu residue may be involved in the receptor-binding or the active site of human insulin.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes
/
Insulina
Idioma:
En
Revista:
Biochem Mol Biol Int
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Año:
1995
Tipo del documento:
Article