The sensitivity of Leishmania species to aminosidine.
J Antimicrob Chemother
; 35(5): 577-84, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-7592170
ABSTRACT
The aminoglycoside, aminosidine exhibited ED50S of between 1 and 5 microM against the amastigotes of Leishmania major and Leishmania tropica in mouse peritoneal macrophages whereas other strains causing New World cutaneous leishmaniasis such as Leishmania braziliensis were more refractory. Aminosidine was also active against all but one of the Leishmania donovani strains tested and when combined with sodium stibogluconate, the drug showed marked potentiation against the amastigotes of L. donovani in vitro and an additive effect in experimentally infected BALB/c mice.
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Base de datos:
MEDLINE
Asunto principal:
Paromomicina
/
Leishmania
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1995
Tipo del documento:
Article