Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
J Med Chem
; 38(6): 890-7, 1995 Mar 17.
Article
en En
| MEDLINE
| ID: mdl-7699704
ABSTRACT
We present the results from a comparative molecular field analysis (CoMFA) of a set of flavone analogs that inhibit HIV-1 integrase-mediated cleavage (3'-processing step) and integration (strand transfer step) in vitro. The results indicate a strong correlation between the inhibitory activity of these flavones and the steric and electrostatic fields around them. CoMFA quantitative structure-activity relationship models with considerable predictive ability (cross-validated r2 as high as 0.8) were obtained.
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Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Modelos Moleculares
/
ADN Nucleotidiltransferasas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1995
Tipo del documento:
Article