Cyclophosphamide effects on immune function of European starlings.
J Wildl Dis
; 30(3): 328-34, 1994 Jul.
Article
en En
| MEDLINE
| ID: mdl-7933273
We developed and tested a battery of immune function assays on adult European starlings (Sturnus vulgaris) exposed to the immunotoxicant cyclophosphamide (CY). Starlings were injected intraperitoneally for three consecutive days with saline or 20 mg/kg CY. Cyclophosphamide did not affect body mass or packed cell volume. However, spleen to body mass ratios and the number of viable spleen cells were lower in CY-treated birds when compared to controls. Peripheral white blood cell numbers were reduced in CY-treated starlings, and the decrease affected all cell types. Phagocytic ability of macrophages cultured from peripheral blood monocytes was impaired in cells from CY-treated birds. Additionally, CY treatment resulted in decreased lymphocyte blastogenesis to the T-cell mitogen Concanavalin A. The hemagglutination response to sheep erythrocytes was lower in birds that had received CY. Thus, these immunological methods detected chemically-induced immune dysfunction in starlings.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Ciclofosfamida
/
Sistema Inmunológico
Idioma:
En
Revista:
J Wildl Dis
Año:
1994
Tipo del documento:
Article