Amino acids and peptides. XXI. Laminin-related peptide analogs including poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.
Chem Pharm Bull (Tokyo)
; 42(4): 917-21, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8020127
ABSTRACT
Laminin-related peptides, Tyr-Ile-Gly-Ser-Arg analogs, were prepared and their inhibitory effects on experimental metastasis were examined. Of the amino acids in the Tyr-Ile-Gly-Ser-Arg sequence, L-Arg was very important and Ile was not essential for the inhibitory effect. To obtain a potent inhibitor of metastasis, hybrids of Tyr-Ile-Gly-Ser-Arg-Gly and 2 types of poly(ethylene glycol) were prepared. The inhibitory effects of the hybrids were more potent than that of Tyr-Ile-Gly-Ser-Arg-Gly.
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Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Polietilenglicoles
/
Melanoma Experimental
/
Laminina
/
Aminoácidos
/
Antineoplásicos
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
1994
Tipo del documento:
Article