Synergistic effect of choline and carnitine on acetylcholine synthesis in neuroblastoma NB-2a cells.
Biochem Biophys Res Commun
; 202(1): 354-9, 1994 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-8037732
An influence of carnitine on acetylcholine synthesis from radiolabeled glucose was monitored in neuroblastoma NB-2a cells. Upon addition of carnitine the distribution of its derivatives was found significantly different than the values published for brain, the level of long-chain acyl derivatives being much higher and reaching 60%. Carnitine itself did not change acetylcholine level. Together with choline (20 microM), carnitine was observed to stimulate (by 36%) acetylcholine synthesis in a synergistic way, which indicated that both substrates could be limiting factors of this process in NB-2a cell line of neuroblastoma.
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Base de datos:
MEDLINE
Asunto principal:
Carnitina
/
Acetilcolina
/
Colina
/
Neuroblastoma
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1994
Tipo del documento:
Article