Pharmacological studies of centrifugation-induced analgesia.
Pharmacol Biochem Behav
; 46(4): 911-5, 1993 Dec.
Article
en En
| MEDLINE
| ID: mdl-8309971
ABSTRACT
Subjecting rats to a brief period of centrifugal rotation produces a brief analgesia (1-2 min) that is similar to that produced by pretreatment with morphine. The effect of the morphine is blocked by naloxone, while that of the centrifugal rotation is only partially blocked by the same dose of naloxone. Cholinergic blocking agents such as scopolamine are also capable of partially blocking the rotational-induced analgesia. The combination of pretreatment with scopolamine plus naloxone is capable of completely blocking the rotational-induced analgesia, suggesting the involvement of both central cholinergic and endogenous opioid components.
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Base de datos:
MEDLINE
Asunto principal:
Rotación
/
Analgesia
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1993
Tipo del documento:
Article