Localized renal cell carcinoma treated by radical nephrectomy. Influence of pathologic data and the importance of DNA ploidy pattern on disease outcome.
Cancer
; 72(7): 2207-12, 1993 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-8374878
ABSTRACT
BACKGROUND:
The course of patients with renal cell carcinoma may be considerably different. Approximately 50% with presumed localized disease have metastases after nephrectomy. Pathologic stage at diagnosis, histologic grade, and histologic type have been considered the most important predictors of prognosis. Nevertheless, subsets of patients within a specified stage and grade may have considerable differences in disease progression and survival.METHODS:
Flow cytometric nuclear DNA analysis was used to study pathologic Stage I or II renal cell carcinoma in 54 patients who underwent radical nephrectomy between 1974 and 1983.RESULTS:
Sixty-three percent of the tumors were diploid, and 37% aneuploid. A DNA diploid pattern was more common among Stage I tumors than Stage II tumors (69% versus 33%; P < 0.04). Progression occurred in 31% of the diploid tumors, whereas among the aneuploid group the progression rate reached 59% (P < 0.06). Considered as a single indicator, DNA ploidy pattern was strongly associated with patient survival. Ten years after surgery 79% of the patients who had diploid tumors and 50% of those with aneuploid tumors were alive (P < 0.02).CONCLUSIONS:
Nuclear DNA ploidy may serve as an important prognostic variable for patients with early stage renal cell carcinoma.
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Base de datos:
MEDLINE
Asunto principal:
Ploidias
/
Carcinoma de Células Renales
/
Neoplasias Renales
/
Nefrectomía
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Cancer
Año:
1993
Tipo del documento:
Article