Preliminary crystallographic studies of an anti-HIV-1 protease antibody that inhibits enzyme activity.
Protein Sci
; 5(5): 966-8, 1996 May.
Article
en En
| MEDLINE
| ID: mdl-8732768
ABSTRACT
F11.2.32, a monoclonal antibody directed against the HIV-1 protease, displays strong inhibitory effects toward the catalytic activity of the enzyme. The antibody cross-reacts with peptides 36-46 and 36-57 from the protease. Crystals of the Fab have been obtained both in the free state and as complexes formed with the protease peptide fragments, 36-46 and 36-57. Diffraction data have been collected for the free and complexed forms of Fab F11.2.32 and preliminary models for the crystal structures were obtained by molecular replacement.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
Antígenos VIH
/
Proteasa del VIH
/
VIH-1
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Inhibidores de la Proteasa del VIH
/
Anticuerpos Monoclonales
Idioma:
En
Revista:
Protein Sci
Asunto de la revista:
BIOQUIMICA
Año:
1996
Tipo del documento:
Article