Studies on the molecular toxicology of buta-1,3-diene and isoprene epoxides.
Toxicology
; 113(1-3): 290-3, 1996 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-8901910
Reactions of ethenyloxirane with amino (RNH2) and thiol (R'SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3. In contrast, 2-ethenyl-2-methyloxirane reacts with amino (RNH2) and thiolate (R'S-) nucleophiles in methanol by regioselective SN2 attack at C-3 ("neo-pentyl" position). However, in pure water or methanol SN1 reaction occurs mainly at C-2.
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Base de datos:
MEDLINE
Asunto principal:
Pentanos
/
Butadienos
/
Hemiterpenos
/
Compuestos Epoxi
Idioma:
En
Revista:
Toxicology
Año:
1996
Tipo del documento:
Article