Hyperkalemia associated with cyclosporine (CsA) use in bone marrow transplantation.
Bone Marrow Transplant
; 19(3): 289-91, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9028560
ABSTRACT
Two adult leukemia patients underwent allogeneic bone marrow transplantation and received cyclosporine (CsA) as part of their immunosuppressive therapy. Despite adequate kidney function, both patients developed hyperkalemia. Cyclosporine was the only pharmaceutical agent to which this electrolyte abnormality could be attributed. Although the mechanism of the hyperkalemia is unclear, it seems to be related to an aldosterone-resistant state. Cyclosporine-induced hyperkalemia is a relatively common occurrence; however, there is only a single 'case report' addressing this phenomenon in bone marrow transplantation patients. We propose both mechanisms and methods of managing CsA-associated hyperkalemia in allogeneic transplantation patients.
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Base de datos:
MEDLINE
Asunto principal:
Trasplante de Médula Ósea
/
Ciclosporina
/
Hiperpotasemia
/
Inmunosupresores
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Bone Marrow Transplant
Asunto de la revista:
TRANSPLANTE
Año:
1997
Tipo del documento:
Article