Association of interleukin 6 release from endothelial cells and pulmonary hypertension in SLE.
J Rheumatol
; 24(3): 489-95, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9058654
ABSTRACT
OBJECTIVE:
To investigate how sera from 37 patients with systemic lupus erythematosus (SLE) stimulate interleukin (IL) 6 release from IL-1beta pretreated endothelial cells and compare these effects to those of sera from 16 normal controls.METHODS:
Endothelial cells pretreated 18 h with IL-1beta (5 U/ml) were incubated 2 h with sera diluted 10-fold with phosphate buffered saline (PBS). IL-6 concentrations in endothelial culture supernatants collected after incubation were measured by ELISA.RESULTS:
Compared with PBS, sera from controls and 24 patients with SLE suppressed IL-6 release from IL-1beta pretreated cells. However, sera from 13 patients with SLE augmented IL-6 release. Of note, sera from 5 patients with pulmonary hypertension induced the highest level of IL-6 release. IgG from control sera suppressed IL-6 release, whereas F(ab')2 did not. Both IgG and F(ab')2 from the sera of patients with SLE with pulmonary hypertension augmented IL-6 release from IL-1beta pretreated cells.CONCLUSION:
IgG antiendothelial cell antibodies from patients with SLE may be associated with the pathogenesis of SLE and pulmonary hypertension.
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Base de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Interleucina-6
/
Hipertensión Pulmonar
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
J Rheumatol
Año:
1997
Tipo del documento:
Article