Diabetes, asymptomatic hyperglycemia, and 22-year mortality in black and white men. The Chicago Heart Association Detection Project in Industry Study.
Diabetes Care
; 20(2): 163-9, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9118765
ABSTRACT
OBJECTIVE:
To assess relationships of diabetes and asymptomatic hyperglycemia at baseline to the risk of cardiovascular disease (CVD) and all-cause (ALL) mortality in employed, white and black middle-aged men. RESEARCH DESIGN ANDMETHODS:
A prospective cohort study of 11,554 white men and 666 black men between the ages 35 and 64 from 1967 to 1973 was conducted using data from the Chicago Heart Association (CHA) Detection Project in Industry 22-year mortality follow-up. cox proportional hazards models, adjusted fro age and other CVD risk factors, were used to estimate the relative risk (RR) and the 95% CI of mortality associated with baseline glycemic status.RESULTS:
Age-adjusted baseline prevalence of clinical diabetes was similar in white (3.7%) and black (4.3%) men; asymptomatic hyperglycemia (glucose post-50-g load > or = 11.1 mmol/l) was present in 11.1% of whites and 7.8% of blacks. After controlling for age, lifestyle, and other CVD risk factors, mortality risk was increased among white men with clinical diabetes (CVD RR 2.51, CI 2.08-3.02; ALL RR 1.88, CI 1.63-2.17) and asymptomatic hyperglycemia (CVD RR 1.18, CI 1.01-1.37; ALL RR 1.24, CI 1.11-1.37), compared with men with postload glucose < 8.9 mmol/l. Risks were similarly, though nonsignificantly (owing to low statistical power), increased among black men with clinical diabetes (CVD RR 1.60, CI 0.60-4.29; ALL RR 1.78, CI 0.97-3.25) and asymptomatic hyperglycemia (CVD RR 1.29, CI 0.61-2.72; ALL RR 1.37, CI 0.85-2.20).CONCLUSIONS:
Asymptomatic hyperglycemia and clinical diabetes appear to confer increased mortality risk in both white and black men. In addition, mortality risk is increased with increased severity of glycemia. These findings indicate the importance of applying efforts to reduce risk factors and prevent diabetes in both blacks and whites.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Población Negra
/
Población Blanca
/
Diabetes Mellitus
/
Hiperglucemia
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Diabetes Care
Año:
1997
Tipo del documento:
Article