The efficacy of exit site povidone-iodine ointment in the prevention of early peritoneal dialysis-related infections.
Am J Kidney Dis
; 29(5): 763-8, 1997 May.
Article
en En
| MEDLINE
| ID: mdl-9159313
ABSTRACT
Infections are the main complications of peritoneal dialysis, and currently there is no established method for prevention. A prospective, randomized, single-blind study was performed to evaluate the efficacy of regular application of povidone-iodine ointment at the catheter site (during the entire time on the study) in peritoneal dialysis. One hundred twenty patients were randomized; three were excluded for not completing the study. Sixty-one patients received application of povidone-iodine and 56 patients received standard care. Povidone-iodine ointment was effective in delaying infectious complications, with a lower proportion of treated patients having infections (exit site and peritonitis) within 140 days of starting dialysis compared with the controls (P = 0.04, Wilcoxon test). This protective benefit was lost after 140 days on dialysis. Staphylococcus aureus infections developed in only two (3.3%) of the treated patients compared with 10 (21.4%) of the controls (P = 0.009), despite the higher rate of S aureus nasal carriage in the treated group (22 of 61 patients [36%] v 14 of 56 patients [25%]).
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Base de datos:
MEDLINE
Asunto principal:
Povidona Yodada
/
Infecciones Bacterianas
/
Diálisis Peritoneal
/
Antiinfecciosos Locales
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
Idioma:
En
Revista:
Am J Kidney Dis
Año:
1997
Tipo del documento:
Article