Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
Science
; 277(5327): 818-21, 1997 Aug 08.
Article
en En
| MEDLINE
| ID: mdl-9242611
ABSTRACT
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
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Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Factor de Necrosis Tumoral alfa
/
Apoptosis
/
Receptores del Factor de Necrosis Tumoral
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article