Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents.
FEBS Lett
; 415(2): 134-8, 1997 Sep 29.
Article
en En
| MEDLINE
| ID: mdl-9350983
ABSTRACT
The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7-36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9-39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding.
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Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Precursores de Proteínas
/
Glucagón
/
Proteínas
/
Núcleo Solitario
/
Receptores de Superficie Celular
/
Ingestión de Alimentos
/
Neuronas
Idioma:
En
Revista:
FEBS Lett
Año:
1997
Tipo del documento:
Article