Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones). Synthesis, structure, antimicrobial activity and genotoxicity.
J Inorg Biochem
; 69(1-2): 101-12, 1998 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-9606941
ABSTRACT
Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(2-hydroxybenzoylhydrazone) (H5dfps) and pyrrole-2,5-dicarboxaldehyde bis(2-picolinoylhydrazone) (H3dfpp) were synthesized and characterized by IR, 1H and 119Sn NMR spectroscopy. X-ray analysis of the complex [Sn(H3dfps)(C6H5)2].(CH3)2SO revealed a pentacoordination around tin through a N,N,O terdentate ligand behaviour of the hydrazone. This complex is the most active compound, exhibiting MIC values of 3 and 12 micrograms/ml against Gram positive and Gram negative bacteria, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in the Salmonella-microsome test.
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Base de datos:
MEDLINE
Asunto principal:
Compuestos Orgánicos de Estaño
/
Daño del ADN
/
Antibacterianos
Idioma:
En
Revista:
J Inorg Biochem
Año:
1998
Tipo del documento:
Article