Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country.
Aliment Pharmacol Ther
; 12(6): 551-5, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9678815
ABSTRACT
BACKGROUND:
A number of triple drug regimens using proton pump inhibitors and two antibiotics have been evaluated in the West and reported to achieve Helicobacter pylori eradication rates of over 90%. In developing countries however, these combinations have neither been well evaluated, nor the optimum treatment for H. pylori infection well defined.AIM:
To compare the combination of a proton pump inhibitor with a nitroimidazole and another antibiotic in eradicating H. pylori infection and healing duodenal ulcer.METHODS:
Sixty consecutive patients with active duodenal ulcer who were positive for H. pylori (by rapid urease test and 14C-urea breath test) were randomized into three treatments groups (1) LAS (n=21) lansoprazole 30 mg o.m., amoxycillin 500 mg q.d.s. and secnidazole 2 g on alternate days for 2 weeks; (2) LCS (n=18) lansoprazole 30 mg o.m., clarithromycin 500 mg b.d. and secnidazole 2 g on alternate days for 1 week; (3) LPS (n=21) lansoprazole 30 mg o.m., pefloxacin 400 mg o.m. and secnidazole 2 g on alternate days for 2 weeks. Urease and breath tests were performed at 0, 6 and 12 weeks to check for H. pylori eradication.RESULTS:
Intention-to-treat eradication rates were as follows LAS 86%, LCS 83%, LPS 71%; the overall ulcer healing rate was 90% at 6 weeks.CONCLUSIONS:
High H. pylori eradication rates were achieved using the amoxycillin- and clarithromycin-based therapies. Fewer side-effects, better compliance and low cost favoured the amoxycillin-based therapy.
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Base de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Pefloxacina
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Claritromicina
/
Inhibidores de la Bomba de Protones
/
Amoxicilina
/
Metronidazol
/
Antiulcerosos
/
Antibacterianos
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Aliment Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
1998
Tipo del documento:
Article