Synthesis, antiviral and antiproliferative activity of some N-benzenesulphonyl-2(2- or 3-pyridylethyl)-benzimidazoles.
Anticancer Drug Des
; 13(5): 397-406, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9702206
ABSTRACT
Some N-benzenesulphonyl-2(2- or 3-pyridylethyl)-benzimidazoles were synthesized and tested in vitro for antiproliferative and antiviral activity. Only one compound displayed a degree of antiproliferative activity against chronic myeloid leukaemia cells. However, a number of them exerted an antiviral effect at micromolar concentrations. The antiproliferative activity and the maximum potency of antiviral activity correlate with the presence of both the 2-pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro group in the benzene ring.
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Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Piridinas
/
Bencenosulfonatos
/
Bencimidazoles
Idioma:
En
Revista:
Anticancer Drug Des
Asunto de la revista:
ANTINEOPLASICOS
/
FARMACOLOGIA
Año:
1998
Tipo del documento:
Article