Intra-individual comparison of 3(R)-BMIPP and 3(S)-BMIPP isomers in humans.
J Nucl Med
; 39(10): 1672-5, 1998 Oct.
Article
en En
| MEDLINE
| ID: mdl-9776266
ABSTRACT
UNLABELLED The racemic 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) is currently used at several centers for myocardial metabolic imaging with SPECT. Recently, the 3(R)-BMIPP isomer showed a 20%-25% higher myocardial uptake and lower liver uptake than 3(S)-BMIPP in fasted rats. The aim of this study was to determine if these differences in myocardial and liver uptake also occur in humans. METHODS:
Iodine-123-labeled 3(R)-BMIPP and 3(S)-BMIPP isomers were injected at rest, on two separate days, in six patients with stable coronary artery disease. Dual-head, whole-body scintigraphy was performed 20 min and 3 hr after injection. SPECT cardiac imaging was performed 60 min after injection.RESULTS:
Myocardial activity averaged (% injected dose +/- s.d.) 3.15 +/- 0.49 versus 3.01 +/- 0.44 at 20 min (p = ns) and 2.64 +/- 0.38 versus 2.55 +/- 0.41 at 3 hr postinjection (p = ns) for the 3(R)-BMIPP and 3(S)-BMIPP isomers, respectively. Liver activity averaged 9.50 +/- 1.18 versus 9.44 +/- 0.66 at 20 min and 5.33 +/- 0.64 versus 5.43 +/- 0.66 at 3 hr, respectively (p = ns). SPECT showed no difference in the distribution of the two isomers between normal and infarcted myocardium.CONCLUSION:
There is no significant difference in myocardial and liver distribution of the 3(R)-BMIPP and 3(S)-BMIPP isomers in humans.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada de Emisión de Fotón Único
/
Radiofármacos
/
Enfermedad Coronaria
/
Ácidos Grasos
/
Radioisótopos de Yodo
/
Yodobencenos
Idioma:
En
Revista:
J Nucl Med
Año:
1998
Tipo del documento:
Article