Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals.
Int J Infect Dis
; 3(1): 39-47, 1998.
Article
en En
| MEDLINE
| ID: mdl-9831675
ABSTRACT
Disseminated Mycobacterium avium complex (DMAC) infection is a common complication of advanced HIV disease, and is an independent predictor of mortality. The clinical features of DMAC infection are fever, weight loss, abdominal pain, anemia, elevated serum alkaline phosphatase, and elevated serum lactate dehydrogenase. The diagnosis is made by blood cultures; clinical diagnosis is unreliable. Chemoprophylaxis of DMAC infection with azithromycin is recommended when the CD4 lymphocyte count is below 50 cells/mm3. Established DMAC infection is treated with clarithromycin plus ethambutol, unless the isolate is macrolide-resistant, in which case the optimal therapy is uncertain. Highly active antiretroviral therapy is important in both prevention and treatment of DMAC infection.
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Base de datos:
MEDLINE
Asunto principal:
Infección por Mycobacterium avium-intracellulare
/
Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Int J Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
1998
Tipo del documento:
Article