Asunto(s)
Antineoplásicos Inmunológicos , Inmunoconjugados , Neoplasias Experimentales , Paclitaxel , Polietilenglicoles/química , Animales , Antineoplásicos Inmunológicos/química , Antineoplásicos Inmunológicos/farmacología , Línea Celular Tumoral , Humanos , Inmunoconjugados/química , Inmunoconjugados/farmacología , Ratones , Ratones Desnudos , Neoplasias Experimentales/tratamiento farmacológico , Neoplasias Experimentales/metabolismo , Neoplasias Experimentales/patología , Paclitaxel/química , Paclitaxel/farmacología , Ensayos Antitumor por Modelo de XenoinjertoRESUMEN
In this work, aligned zinc oxide (ZnO) nanorods were selectively hydrothermally grown on acetate-seeded spots on a gold substrate; the nanorods had an average length and diameter of 1.7µm and 240nm, respectively. Melatonin was imprinted into poly(ethylene-co-vinyl alcohol), EVAL, which was coated onto ZnO nanorod arrays. The ZnO nanorods not only increased the surface area for sensing target molecules, but also constituted an optical sensing element, as the ZnO fluorescence decreases when targets bind to the imprinted EVAL film; the fluorescence decrease, as a function of melatonin concentration, is well fit by a Langmuir adsorption isotherm. Poly(ethylene-co-vinyl alcohol) with 44mol% ethylene showed the best imprinting effectiveness (ratio of the fluorescence decrease on binding melatonin to imprinted vs. non-imprinted EVAL-coated ZnO nanorod arrays) among the several compositions studied. In real urine analysis, the MIP films responded linearly to added (exogenous) melatonin, even in the presence of many possible interfering compounds in urine. This demonstrates the feasibility of using these MIPs as part of a total urinalysis MIP system.
Asunto(s)
Técnicas Biosensibles , Melatonina/aislamiento & purificación , Impresión Molecular , Nanotubos/química , Fluorescencia , Humanos , Melatonina/orina , Polivinilos/química , Propiedades de Superficie , Óxido de Zinc/químicaRESUMEN
PURPOSE: To investigate the condition of four kinds of noncarious hard tissue lesions of the teeth in teachers of one university in Shanghai municipality and provide guidance about oral health care. METHODS: The table and the standard on oral health survey authorized by WHO were adopted, condition of four kinds of noncarious hard tissue lesions of teeth in 776 teachers of East China University of Science was investigated and analyzed using SPSS16.0 software package. RESULTS: The average wedge-shaped defect teeth was 5.54±3.87, the incidence was 30.41%, caries incidence of the first bicuspid was the highest(29.52%). The incidence of tetracycline pigmentation teeth was 3.09%, the incidence of enamel hypoplasia was 2.06%, and the incidence of dental fluorosis was 1.55%. CONCLUSIONS: The average wedge-shaped defect teeth is higher than the data over the country, the incidence of dental textural anomaly is lower. The behaviors of oral health care of university teachers in Shanghai municipality remains to be further strengthened.