Smile esthetics from the layperson's perspective.

INTRODUCTION: Computer-based smile esthetic surveys based on slider technology allow more precise control of variables and the possibility of obtaining continuous data. Variations in the perception of smiles from different facial perspectives have not been resolved. The objective of this study was to quantify the ideal and the range of acceptable values for smile variables judged by laypersons from a full-face perspective for comparison with lower-face data. METHODS: Mirrored and symmetric male and female full faces previously determined by peers to be of average attractiveness were used. Ninety-six laypersons judged these smile variables: smile arc, buccal corridor fill, maxillary gingival display, maxillary midline to face, maxillary to mandibular midline discrepancy, overbite, central incisor gingival margin discrepancy, maxillary anterior gingival height discrepancy, incisal edge discrepancy, and cant. The judges manipulated the variables using adjustable image technology that allowed the variable to morph and appear continuous on a computer monitor. Medians for each smile variable were compiled, and the Fleiss-Cohen weighted kappa statistic was calculated to measure reliability. Multiple randomization tests with adjusted P values were used to compare these data with those for lower-face views. RESULTS: Reliability ranged from 0.25 for ideal overbite to 0.60 for upper midline to face, except for upper and lower buccal corridor limits, which each had a kappa value near 0. There were no statistically significant differences between the ratings of male and female raters. The following variables showed statistically and clinically significant differences (>1 mm) when compared with the lower-face view: ideal smile arc, ideal buccal corridor, maximum gingival display, upper to lower midline, and occlusal cant. Although the smile arc values differed because of model lip curvature variations, the principle of tracking the curve of the lower lip was confirmed. For the full-face view, the raters preferred less maximum gingival display, less buccal corridor, more upper to lower midline discrepancy, and less cant of the occlusal plane. CONCLUSIONS: Reliability was fair to moderate with the exception of the buccal corridor limits. Most variables showed no clinically meaningful differences from the lower-face view. The acceptable range was quite large for most variables. Detailed knowledge of the ideal values of the various variables is important and can be incorporated into orthodontic treatment to produce an optimal esthetic smile.

Smile esthetics from patients' perspectives for faces of varying attractiveness.

INTRODUCTION: Delivering an attractive smile is a key element in orthodontic patient satisfaction. Smile characteristics can be affected by the facial context. The purpose of this study was to investigate smile esthetics related to facial attractiveness and sex of the model. METHODS: Attractive, average, and unattractive model faces (2 of each; 3 male, 3 female) determined by peer ratings were combined with 10 smile variables (buccal corridor, smile arc, maxillary gingival discrepancy, gingival display, incisal-edge discrepancy, cant, overbite, central-incisor gingival margin discrepancy, and maxillary midline to face, and maxillary midline to mandibular midline). Each smile characteristic was altered digitally and presented with slider technology to allow a continuous range of choices. Raters chose the ideal and the limits of acceptability. The variables were divided into 6 separate surveys and rated 96 times. Reliability was assessed by answering each question twice. RESULTS: Individual smile variable reliability ranged from fair to excellent, except for the buccal corridor. Clinically significant values were defined as greater than 1.0 mm with statistical significance (P <0.05). Rater sex did not make a difference. Clinical significance was found for smile arc, gingival display, and maxillary midline to face. For females, accentuated smile arcs were preferred for the unattractive and attractive models compared with the average models. The opposite was found for male models. More gingival display was preferred for the attractive and unattractive male and female models compared with the average models. Attractive models were allowed less midline deviation. CONCLUSIONS: Facial attractiveness and model sex impacted smile variables with a facial context, except for occlusal cant. These smile characteristics with a facial context should be considered when diagnosing and planning treatment for an orthodontic patient.

Orthodontic appliance preferences of children and adolescents.

INTRODUCTION: Although attractiveness and acceptability of orthodontic appliances have been rated by adults for themselves and for adolescents, children and adolescents have not provided any substantial data. The objective of this study was to evaluate preferences and acceptability of orthodontic appliances in children and adolescents. METHODS: Images of orthodontic appliances previously captured and standardized were selected and incorporated into a computer-based survey. Additional images of shaped brackets and colored elastomeric ties, as well as discolored clear elastomeric ties, were captured and incorporated onto existing survey images with Photoshop (Adobe, San Jose, Calif). The survey displayed 12 orthodontic appliance variations to 139 children in 3 age groups: 9 to 11 years (n = 45), 12 to 14 years (n = 49), and 15 to 17 years (n = 45). The subjects rated each image for attractiveness and acceptability. All images were displayed and rated twice to assess rater reliability. RESULTS: Overall reliability ratings were r = 0.74 for attractiveness and k = 0.66 for acceptability. There were significant differences in bracket attractiveness and acceptability in each age group. The highest-rated appliances were clear aligners, twin brackets with colored ties, and shaped brackets with and without colored ties. Colored elastomeric ties improved attractiveness significantly over brackets without colored ties for children in the 12-to-14 year group. There was a tendency for older subjects to rate clear orthodontic appliances higher than did younger subjects. Ceramic brackets with discolored ties tended to be rated lower than ceramic brackets with new ties and scored lowest in acceptability and attractiveness in all age groups. Girls rated shaped brackets significantly higher than did boys. CONCLUSIONS: Children's preferences for orthodontic appliances differ by age and sex. Child and adolescent preferences differ from adult preferences.

Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer.

PURPOSE: To determine the tolerability and pharmacokinetics of CI-1033 given daily for 7 days of a 21-day cycle. Tumor response and changes in erbB receptor tyrosine kinase activity in tumor and skin tissue were examined, and modulation of potential biomarkers in plasma was explored. DESIGN: This was a dose-finding phase I study in patients with advanced solid malignancies. Patients were evaluated for safety, pharmacokinetics, and tumor response. Pharmacodynamic markers, such as Ki67, p27, and erbB receptor status, were assessed in tumor and skin tissue using immunohistochemical and immunoprecipitation methodologies. Plasma biomarkers HER2, vascular endothelial growth factor, interleukin-8, and matrix metalloproteinase-9 were evaluated using immunologic techniques. RESULTS: Fifty-three patients were enrolled in the study. Dose-limiting toxicity (emesis, persistent rash, and mouth ulcer) was observed at 750 mg. The maximum tolerated dose was 650 mg. There were no confirmed objective responses. CI-1033 treatment showed down-regulation of epidermal growth factor receptor, HER2, and Ki67 in a variety of tumor tissues and up regulation of p27 in skin tissue. Plasma HER2 was reduced following CI-1033 administration, but no consistent change in vascular endothelial growth factor, interleukin-8, or matrix metalloproteinase-9 was noted. CI-1033 plasma concentrations were proportional to dose. CONCLUSION: The safety and pharmacokinetic profile of CI-1033 was favorable for multidose oral administration. Evidence of modulation of erbB receptor activity in tumor and skin tissue was accompanied by changes in markers of proliferation and cell cycle inhibition. Additional clinical trials are warranted in defining the role of CI-1033 in the treatment of cancer and further assessing the utility of antitumor markers.

Esthetics and smile characteristics evaluated by laypersons.

OBJECTIVE: To collect data regarding Canadian laypersons' perceptions of smile esthetics and compare these data to US data in order to evaluate cultural differences. MATERIALS AND METHODS: Using Adobe Photoshop 7, a digital image of a posed smile of a sexually ambiguous lower face was prepared so that hard and soft tissue could be manipulated to alter buccal corridor (BC), gingival display (GD), occlusal cant (OC), maxillary midline to face discrepancy (MMFD), and lateral central gingival discrepancy (LCGD). Adult Canadian laypersons (n  =  103) completed an interactive computer-based survey of 29 randomized images to compare smile preferences for these variables. The custom survey was developed to display fluid, continuously appearing modifiable smile variables using MATLAB R2008 for presentation. These data were compared with previously published data for US laypersons. Statistical inference was determined using Wilcoxon rank sum tests. RESULTS: Canadian laypersons were more sensitive in detecting deviations from ideal and had a narrower range of acceptability thresholds for BC, GD, OC, MMFD, and LCGD. Ideal esthetic values were significantly different only for BC. CONCLUSIONS: It appears that cultural differences do exist related to smile characteristics. Clinically significant differences in the preference of the smile characteristics were found between Canadian and US laypersons. Canadian laypersons, on average, were more discriminating to deviations from ideal and had a narrower range of acceptability.