RESUMEN
Reverse thermally induced separation (RTIPS) was used to obtain a separation membrane with a better internal structure for a higher water flux and a surface that could easily form a hydration layer. In comparison to the traditional modification method, this work focused on the aspect that the internal structure obtained by changing the membrane-making method provided easier adhesion conditions for the dopamine/TiO2 hybrid nanoparticles (DA/TiO2 HNPs) obtained by biomimetic mineralization. It provided a basis for exploring the variation in adhesion with the water bath temperature and the amount of titanium added through the study of turbidity point, SEM images, water contact angle, thermogravimetric test, EDX, AFM, XPS, FTIR and other test results. The SEM images proved that the membrane obtained through the RTIPS method had a porous surface and spongy internal structure, furthermore, additional polymers were adsorbed. Use of EDX demonstrated that biomimetic mineralization prevented the production of agglomerated titanium dioxide. XPS and FTIR spectra confirmed the introduction and immobilization of HNP aggregation. Moreover, a decrease in the surface roughness and water contact angle further suggested an improvement in the hydrophilicity of the modified membrane. The introduction of HNP at a higher water bath temperature helped increase the water flux up to ten times, moreover, the oil-water separation efficiency could still reach over 99.50%. Lastly, a cycle test of the modified membrane under the optimal conditions helped confirm that the membrane forming conditions at this time could provide a better environment for the formation of the hydrophilic layer, which was conducive to the recycling of the separation membrane. In summary, more fixed more hydrophilic particles could be obtained through the RTIPS method based on biomimetic mineralization to prevent the accumulation of titanium dioxide, thus helping improve permeability and anti-fouling of the membrane.
Asunto(s)
Biónica , Membranas Artificiales , Polímeros/química , SulfonasRESUMEN
In this study, to mitigate the permeability-selectivity trade-off effect, Pluronic F127 (F127) and HKUST-1 were employed to construct high-performance membranes based on the reverse thermally induced phase separation (RTIPS) method. F127, as a hydrophilic modifier, was applied to increase permeability and resist polyethersulfone (PES) membrane fouling, while the collapse of HKSUT-1 caused by its instability in pure water improved the permeability and selectivity of the membrane. Characterizations demonstrated the successful synthesis of HKUST-1, together with the successful introduction of HKSUT-1 and F127 in PES membranes. It was observed that the membrane prepared by the RTIPS process possessed a uniformly porous surface and sponge-like cross-section with excellent mechanical properties, higher permeability, and selectivity compared to the dense skin and finger-like cross-section of the membrane prepared by the nonsolvent induced phase separation (NIPS) method. Moreover, the permeation and bovine serum albumin (BSA) rejection rate of the optimal membrane reached 2378 L/m2 h and 89.3%, respectively, which were far higher than those of the pure membrane. Hydrophilic F127 and many microvoids formed by the collapse of HKUST-1, played an important role in excellent antifouling properties, high permeability, and selectivity by pure water flux (PWF), flux recovery rate (FRR), BSA flux, and COD removal rate tests. Overall, the membrane with F127 and HKSUT-1 prepared via the RTIPS method not only obtained excellent antifouling properties but also mitigated the permeability-selectivity trade-off.
Asunto(s)
Membranas Artificiales , Estructuras Metalorgánicas , Permeabilidad , Polietilenos , Polímeros , Polipropilenos , SulfonasRESUMEN
The molecular structure of polymers has a great influence on their thermoelectric properties; however, the relationship between the molecular structure of a polymer and its thermoelectric properties remains unclear. In this work, two benzo[1,2-b:4,5-b']dithiophene (BDT)-based conjugated polymers are designed and synthesized, which contain alkyl side chains or polar side chains. The effects of the polymer side chain on the physicochemical properties are systematically investigated, especially the thermoelectric performance of the polymers after doping with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane. It is found that the BDT-based conjugated polymer with polar side chains exhibits good miscibility with the dopants, leading to higher thermoelectric properties than those of the polymer with alkyl side chains. This work can serve as a reference for the future design of high-performance organic thermoelectric polymers.
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Polímeros/química , Temperatura , Tiofenos/química , Conductividad Eléctrica , Estructura Molecular , Tamaño de la Partícula , Polímeros/síntesis química , Propiedades de Superficie , Tiofenos/síntesis químicaRESUMEN
Plastic products are widely distributed worldwide and continue to have a negative impact on the environment and organisms. Intertidal regions, which interface between upland and marine ecosystems, are regions of high ecological importance and serve as repositories for a variety of plastic wastes. However, ecological risk assessments of microplastics (MPs) in these transitional environments are still scarce. In this study, the morphological characteristics and spatial distribution of MPs in the intertidal surface sediments of Haizhou Bay were analyzed, and an ecological risk assessment framework for MPs was developed. Overall, the average abundance of MPs in the sediments was 2.31 ± 1.35 pieces/g dw. The size of the MPs was mainly less than 1 mm, and the main shape, color and polymer type of the MPs were mainly fibrous (58%), blue (30%), and PVC (22%), respectively. Cluster analyses showed that the sites could be well distinguished by size and polymer type but not by MP shape and color. According to the hazard scores, most of the sites in this area belonged to a risk level of IV, while the pollution loading index (PLI) showed that most of the sites belonged to a risk level of II. The ecological toxicity risk from the species-sensitive distribution (SSD) model showed that one-third of the sites had ecological MPs toxicity risks to marine organisms. We believe that normalized and standardized assessment methods should be implemented to monitor and manage the risk of MPs in the intertidal sediments. Particularly, the multiple dimensions, standard abundance of MPs, as well as MPs ingestion in the intertidal organisms, should be fully considered in the next step.
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Microplásticos , Contaminantes Químicos del Agua , Ecosistema , Monitoreo del Ambiente/métodos , Sedimentos Geológicos , Microplásticos/análisis , Plásticos , Polímeros , Medición de Riesgo , Contaminantes Químicos del Agua/análisisRESUMEN
OBJECTIVE: To explore the effect of the whole-process health management model on the compliance of oral warfarin treatment in patients with non-valvular atrial fibrillation in primary hospitals. METHODS: We retrospectively analyzed the clinical data of 130 patients with non-valvular atrial fibrillation treated in the Department of Cardiovascular Medicine, Hai'an People's Hospital from January 2019 to December 2019. Among them, 63 patients who received routine continuing care were included in the control group, and 67 patients treated with whole-course health management model of primary hospitals were included in the observation group. The two groups were compared in terms of the following parameters: Warfarin anticoagulation knowledge, medication compliance, compliance rate (international normalized ratio, INR) monitoring, bleeding events (gingival bleeding, subcutaneous bleeding, gastrointestinal bleeding, etc.), embolic events (vascular thrombosis), negative emotions before and after management, and patient satisfaction. Logistic analysis was used to analyze independent risk factors affecting the effect of warfarin anticoagulation in patients with non-valvular atrial fibrillation. RESULTS: Compared with the control group, the warfarin anticoagulation knowledge, medication compliance, and INR compliance rate of the observation group were significantly higher, and the incidence of adverse events was significantly lower. Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores were not significantly different between the two groups before management. After management, SAS and SDS scores decreased significantly in both groups, and were lower in the observation group compared with the control group. The management satisfaction was also significantly higher in the observation group. CONCLUSION: Compared with the conventional continuation care model, the whole-process management in primary hospitals can improve patients' compliance with medical advice and treatment efficacy, with lower risk of bleeding and higher patient satisfaction, providing a better option for the out-of-hospital management of anticoagulation for non-valvular atrial fibrillation patients. Age, hypertension, diabetes, knowledge of warfarin anticoagulation and medication compliance were independent risk factors for the effect of warfarin anticoagulation in patients with non-valvular atrial fibrillation.
RESUMEN
In order to improve the hydrophobicity of traditional polyethersulfone (PES) membranes, this study combined the reverse thermally induced phase separation (RTIPS) method with the constructed bimetallic polyphenol networks (BMPNs) to prepare hydrophilic anti-fouling membranes. As for BMPNs, tannic acid (TA) was served as an intermediate to construct both the inner and surface hydrophilic layers of the PES membranes. On the one hand, etching Zeolitic imidazolate framework-8 (EZIF-8) with synergistic etching and surface functionalization via TA not only retained the high pore structure of MOFs, but also had good hydrophilicity. On the other hand, the MPN hydrophilic layer was formed on the membrane surface by the combination of TA from the surface of EZIF-8 and iron ions in the coagulation bath. Therefore, BMPNs structure penetrated the interior and surface of PES membrane, which greatly improved the hydrophilic properties. In addition, the membrane with porous surfaces and spongy cross sections by RTIPS method improved the permeability and mechanical properties of the membrane by several times compared with the membrane via NIPS method. The obtained membranes in this experiment showed excellent permeability, just like pure water flux reached 1662.16 L/m2 h, while BSA rejection rate remained at 92.78%. Compared with pure membrane, it showed a better flux recovery rate (FRR = 83.33%) after cleaning, and the reduction of irreversible (Rir = 16.67%) fouling indexes indicated that the adsorption of protein was inhibited. These results suggested that the hydrophilic anti-fouling PES membranes prepared by this method possessed great application potential in membrane separation technology.
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Incrustaciones Biológicas , Polifenoles , Incrustaciones Biológicas/prevención & control , Interacciones Hidrofóbicas e Hidrofílicas , Polímeros , Porosidad , SulfonasRESUMEN
Most chemotherapy currently available for cancer treatment has limited potential to successful clinical cancer therapy, mainly due to low encapsulating capacity of drugs and unavailable pharmacologically beneficial concentrations at the tumor site. Herein, a novel yet simple strategy is developed to enhance drug encapsulating capacity and localized drug concentration using an injectable hydrogel based on thiolated chitosan (TCS) and poly(ethylene glycol) diacrylate (PEGDA). Almost 100% of encapsulating capacity is achieved when anti-cancer drug curcumin is encapsulated in the system. The interaction of curcumin with PEGDA is determined by fluorescence spectroscopy and the binding constant is calculated, followed by a simulation by a docking study using AutoDock. To improve the anti-tumor activity and achieve effective local concentrations, lysozyme is introduced into the system. Sustained curcumin release in a controlled lysozyme-responsive behaviour is observed, which enables the drug concentration to reach the therapeutic threshold promptly. The system displays efficient intracellular curcumin release to promote cancer cells apoptosis in vitro. In addition, the system effectively delays the tumor growth and reduces adverse effects in tumor-bearing nude mice. The strategy of localized, high encapsulation of drug by using an injectable hydrogel would be particularly beneficial with many insoluble anti-cancer drugs.
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Curcumina/química , Hidrogel de Polietilenoglicol-Dimetacrilato/química , Quitosano/química , Portadores de Fármacos/químicaRESUMEN
Thrombotic events affect many individuals in a number of ways, all of which can cause significant morbidity and mortality. Nattokinase (NK), as a novel thrombolytic drug, has been used for thrombolytic therapy. It not only possesses plasminogen activator activity, but also directly digests fibrin through limited proteolysis. However, it may undergo inactivation and denaturation in the harsh external environment. In this study, a multiarm-polyethylene glycol-polyglutamic acid peptide dendrimer was fabricated and used as a carrier for NK protection and delivery. Different arm numbers of polyethylene glycol-polyglutamic acid peptide dendrimers (x-PEG(G3 )x , x = 2, 4, 6, 8) were designed, prepared, and characterized by 1 H NMR and FTIR. Then, x-PEG(G3 )x were loaded with NK to form nanocomposites. Their size and morphology were determined by dynamic light scattering and transmission electron microscopy. Enzyme activity was evaluated via UV-Vis absorbance spectra, fluorescence spectra, circular dichroism spectra, and zeta potential measurements. The study reveals that the obtained x-PEG(G3 )x /NK nanocomposites possess high enzyme activity. In addition, the nanocomposites show increased viability of rat macrophage cells, and excellent thrombolysis ability in vitro and in vivo. This work establishes a multiarm-polyethylene glycol-polyglutamic acid peptide dendrimer with potential application in NK carrier and thrombolytic therapy. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1687-1696, 2018.
Asunto(s)
Dendrímeros/química , Portadores de Fármacos/química , Fibrinolíticos/administración & dosificación , Péptidos/química , Polietilenglicoles/química , Ácido Poliglutámico/análogos & derivados , Subtilisinas/administración & dosificación , Trombosis/tratamiento farmacológico , Animales , Dendrímeros/síntesis química , Portadores de Fármacos/síntesis química , Fibrinolíticos/uso terapéutico , Masculino , Péptidos/síntesis química , Ácido Poliglutámico/síntesis química , Ratas , Subtilisinas/uso terapéutico , Trombosis/patologíaRESUMEN
The synthesis and properties of CO2 responsive and fluorescent dendritic polymers, poly(amido amine)/Pluronic F127 (PAMAM/F127), are reported in this paper. The morphologies and sizes of PAMAM/F127 dendritic polymers were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). PAMAM/F127 dendritic polymers showed unimolecular micelle morphologies at low concentrations, and changed to multimolecular micelles at higher concentrations. Additionally, fluorescence spectra and confocal laser scanning microscopy images showed that PAMAM/F127 dendritic polymers exhibited a fluorescent enhancement response to the presence of CO2. Apart from that, the release behavior of PAMAM/F127 gels under simulated body fluids was investigated by choosing curcumin as the hydrophobic drug. The results indicated that PAMAM/F127 dendritic polymers can be used to improve the solubility of curcumin, and the drug released faster in the presence of CO2. Such CO2 responsive fluorescent dendritic polymers are potentially applicable in cellular imaging or drug controlled release.
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Dióxido de Carbono/química , Poloxámero/química , Curcumina/química , Dendrímeros/química , Sistemas de Liberación de Medicamentos , Liberación de Fármacos , Humanos , Luz , Espectroscopía de Resonancia Magnética , Micelas , Microscopía Confocal , Microscopía Electrónica de Transmisión , Dispersión de Radiación , Solubilidad , Espectrometría de Fluorescencia , Espectroscopía Infrarroja por Transformada de Fourier , TemperaturaRESUMEN
In this work, thiolated chitosan/alginate composite microparticulates (CMPs) coated by Eudragit S-100 were developed for colon-specific delivery of 5-aminosalicylic acid (5-ASA) and curcumin (CUR), and the use of it as a multi drug delivery system for the treatment of colitis. The physicochemical properties of the CMPs were evaluated. In vitro release was performed in gradually pH-changing medium simulating the conditions of different parts of GIT, and the results showed that the Eudragit S-100 coating has a pH-sensitive release property, which can avoid drug being released at a pH lower than 7. An everted sac method was used to evaluate the mucoadhesion of CMPs. Ex vivo mucoadhesive tests showed CMPs have excellent mucosa adhesion for the colonic mucosa of rats. In vivo treatment effect of enteric microparticulates systems was evaluated in colitis rats. The results showed superior therapeutic efficiency of this drug delivery system for the colitis rats induced by TNBS. Therefore, the enteric microparticulates systems combined the properties of pH dependent delivery, mucoadhesive, and control release, and could be an available tool for the treatment of human inflammatory bowel disease.
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Colon/metabolismo , Curcumina/administración & dosificación , Portadores de Fármacos/química , Mesalamina/administración & dosificación , Mesalamina/química , Ácidos Polimetacrílicos/química , Animales , Quitosano/química , Colitis/tratamiento farmacológico , Colon/inmunología , Colon/patología , Curcumina/química , Curcumina/uso terapéutico , Enfermedades Inflamatorias del Intestino , Mesalamina/uso terapéutico , RatasRESUMEN
With the fast development of cell therapy, there has been a shift toward the development of injectable hydrogels as cell carriers that can overcome current limitations in cell therapy. However, the hydrogels are prone to damage during use, inducing cell apoptosis. Therefore, this study was carried out to develop an injectable and self-healing hydrogel based on chondroitin sulfate multiple aldehyde (CSMA) and N-succinyl-chitosan (SC). By varying the CSMA to SC ratio, the hydrogel stiffness, water content, and kinetics of gelation could be controlled. Gelation readily occurred at physiological conditions, predominantly due to a Schiff base reaction between the aldehyde groups on CSMA and amino groups on SC. Meanwhile, because of the dynamic equilibrium of Schiff base linkage, the hydrogel was found to be self-healing. Cells encapsulated in the hydrogel remained viable and metabolically active. In addition, the hydrogel produced minimal inflammatory response when injected subcutaneously in a rat model and showed biodegradability in vivo. This work establishes an injectable and self-healing hydrogel derived from carbohydrates with potential applications as a cell carrier and in tissue engineering.
Asunto(s)
Materiales Biocompatibles/química , Materiales Biocompatibles/toxicidad , Sulfatos de Condroitina/química , Sulfatos de Condroitina/toxicidad , Hidrogel de Polietilenoglicol-Dimetacrilato/química , Hidrogel de Polietilenoglicol-Dimetacrilato/toxicidad , Animales , Supervivencia Celular/efectos de los fármacos , Tratamiento Basado en Trasplante de Células y Tejidos , Estabilidad de Medicamentos , Células HeLa , Humanos , Masculino , Ratas , Ingeniería de TejidosRESUMEN
With the aim of improving fertilizer use efficiency and minimizing the negative impact of nitrogen pollution, a new multifunctional slow-release fertilizer was prepared by recovery of ammonium from aqueous solutions onto a superabsorbent composite. An eco-friendly superabsorbent composite based on wheat straw (WS) was synthesized and used as the carrier to control the release of nutrients. The adsorption studies with NH4⺠indicated that the superabsorbent composite showed good affinity for NH4âº, with an adsorption capacity of 7.15 mmol g⻹ when 20 wt % of WS was incorporated and that the adsorption system can reach equilibrium within 40 min. Afterward, the feasibility of reusing the composite as a multifunctional slow-release nitrogen fertilizer was investigated. The results showed that the product with good water-retention and slow-release capacities could regulate soil acidity and was economical and eco-friendly for application in agriculture and horticulture.
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Compuestos de Amonio/aislamiento & purificación , Fertilizantes , Tallos de la Planta/química , Triticum/química , Acrilamidas/química , Acrilatos/química , Resinas Acrílicas/química , Adsorción , Agricultura/economía , Alcanosulfonatos/química , Compuestos de Amonio/análisis , Compuestos de Amonio/economía , Estudios de Factibilidad , Fertilizantes/análisis , Fertilizantes/economía , Tecnología Química Verde , Suelo/química , Solubilidad , Residuos/análisis , Residuos/economíaRESUMEN
Comb-shaped copolymers comprised of hydrophobic and hydrophilic blocks are self-assembled in aqueous solution, which results that they are suitable for delivery of hydrophobic drug molecules. Chitosan (CS) is an important biomaterial used widely in medical applications. Herein, a comb-shaped cationic copolymer composed of long biocompatible CS main chains and short PNIPAAm side chains was prepared via atom transfer radical polymerization (ATRP) by attaching an ATRP initiating group to N-phthaloyl chitosan. By subsequent removal of the protective groups on N-phthaloyl chitosan-graft-poly(N-isopropylacrylamide) (PHCS-g-PNIPAAm) copolymer with N(2)H(4)·H(2)O lead to the polymer pendant amino groups, this study attempted to synthesize a pH/temperature multi-responsive material. This chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymer is self-assembled in aqueous solution into stimuli-responsive core-shell micelles with hydrodynamic diameters of about 170 nm. Structural organization and solution behavior were then investigated utilizing (1)H NMR spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS).
Asunto(s)
Acrilamidas , Materiales Biocompatibles , Quitosano , Polímeros , Acrilamidas/síntesis química , Acrilamidas/química , Resinas Acrílicas , Materiales Biocompatibles/síntesis química , Materiales Biocompatibles/química , Quitosano/química , Concentración de Iones de Hidrógeno , Interacciones Hidrofóbicas e Hidrofílicas , Espectroscopía de Resonancia Magnética , Microscopía Electrónica de Transmisión , Polímeros/síntesis química , Polímeros/química , Soluciones/química , Temperatura , Agua/químicaRESUMEN
Cationic polymers have been widely used as drug delivery systems. Herein, an oxidized sodium alginate/chitosan (OSA/CS) core-shell microgel was prepared via water-in-oil emulsion method. Morphological properties of the resulting microgel were determined by transmission electron microscopy, hydrodynamic diameter of the microgel was characterized by dynamic light scattering. The objective of this work was to achieve the colon-specific delivery of an antiulcerative colitis drug using a fully nontoxic carrier. 5-aminosalicylic acid (5-ASA) was chosen as a model drug, which is rapidly absorbed before entering the colon, thus it is necessary to develop a colon-specific delivery system for it. The in vitro drug release profile was established in buffer solutions with 0.1 M HCl/NaCl (pH 1.2) and 0.1 M phosphate buffered saline (pH 7.4) at 37 °C. The results indicated that this OSA/CS core-shell microgel inhibited the release of 5-ASA in stomach to a certain extent and is degradable in physiological conditions. Due to the excellent biocompatible nature of CS and OSA, this core-shell microgel has good biocompatibility and may have potential applications in oral controlled drug delivery systems.
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Alginatos/química , Quitosano/química , Geles/síntesis química , Geles/farmacocinética , Mesalamina/administración & dosificación , Mesalamina/farmacocinética , Implantes Absorbibles , Adsorción , Alginatos/síntesis química , Alginatos/farmacocinética , Quitosano/síntesis química , Quitosano/farmacocinética , Portadores de Fármacos/síntesis química , Portadores de Fármacos/química , Portadores de Fármacos/farmacocinética , Geles/química , Ácido Glucurónico/síntesis química , Ácido Glucurónico/química , Ácido Glucurónico/farmacocinética , Ácidos Hexurónicos/síntesis química , Ácidos Hexurónicos/química , Ácidos Hexurónicos/farmacocinética , Ensayo de Materiales , Modelos Biológicos , Nanosferas/química , Oxidación-Reducción , Tamaño de la Partícula , Polímeros/síntesis química , Polímeros/química , Polímeros/farmacocinéticaRESUMEN
A novel poly((2-dimethylamino) ethyl methacrylate-glycidyl methacrylate)-alginate (P(DMAEMA-GMA)alginate) semi-IPN hydrogel was synthesized via radical polymerization of the double bonds and ring-opening of the epoxy groups without using catalyst and cross-linker. (1)H-NMR, FT-IR and DSC data were consistent with the expected structures for the hydrogels. The interior morphology of the hydrogels was also investigated by SEM. The swelling ratio and compressive strength of the hydrogels were measured. The semi-IPN hydrogel had pH and temperature sensitivity, and pH-sensitive points of all hydrogels were found to be at pH 5.0. The release behavior of the model drug, aminophylline, was found to be dependent on the hydrogel composition and environment pH, which manifests that these materials have potential applications as intelligent drug carriers.
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Alginatos/química , Aminofilina/química , Liberación de Fármacos , Hidrogeles/química , Polimerizacion , Polímeros/química , Ácidos Polimetacrílicos/química , Temperatura , Adsorción , Animales , Bovinos , Portadores de Fármacos/química , Ácido Glucurónico/química , Ácidos Hexurónicos/química , Concentración de Iones de Hidrógeno , Fenómenos Mecánicos , Desnaturalización Proteica , Albúmina Sérica Bovina/químicaRESUMEN
Covalent functionalization of azide-modified SiO(2) with well-defined, alkyne-terminated poly(N-isopropylacrylamide) was accomplished by the Cu(I)-catalyzed [3 + 2] Huisgen cycloaddition. The alkyne-terminated RAFT chain transfer agent was first synthesized, and then the alkyne-terminated thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) with different molecular weights were synthesized by the RAFT of NIPAM monomer. The polymerization kinetics and the evolution of number-average molecular weights (M(n)), and polydispersities (M(w)/M(n)), with monomer conversions were investigated. A copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "grafting to" method was used to attach thermoresponsive polymers onto the exterior surface of SiO(2) nanoparticles which produced relatively high grafting density. The as-synthesized hybrid nanoparticles showed thermoresponsive behavior and were characterized by FTIR, XPS, TGA, DLS, and TEM, etc.
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Acrilamidas/química , Nanopartículas/química , Polímeros/química , Dióxido de Silicio/química , Resinas Acrílicas , Catálisis , Química Clic , Cobre/química , Cinética , Nanopartículas/ultraestructura , Polimerizacion , Espectroscopía Infrarroja por Transformada de Fourier , TemperaturaRESUMEN
Graft copolymerization of amino group-terminated poly((2-dimethylamino) ethyl methacrylate) (PDMAEMA-NH2) onto oxidized sodium alginate (OSA) was reacted without using a catalyst. The structure of the graft was investigated by Fourier transform infrared (FT-IR) spectroscopy. The OSA-g-PDMAEMA gel beads were prepared by dropping the aqueous solution of the graft copolymer into CaCl2 aqueous solution. The effects of pH and ionic strength on the swelling behaviors of the gel beads were studied. The results indicate that the gel beads have pH and ionic strength sensitivity. Bovine serum albumin (BSA) was entrapped in the beads and the in vitro drug release profiles were established in buffer solution with pH 1.8 (HCl), pH 7.4 (KH2PO4-NaOH), and 0.9% (w/v) NaCl at 37 degrees C. The results showed that the oral delivery of proteins can be controlled by adjusting the graft percentage (G, %), pH and ionic strength. According to this study, the OSA-g-PDMAEMA gel beads could be suitable for the oral delivery of proteins.