High resolution 2D dose measurement device based on a few long scintillating fibers and tomographic reconstruction.

PURPOSE: Patient-specific QA of highly conformal radiotherapy treatments are usually conducted using 2D or 3D dosimetry of the incident dose distribution in a water-equivalent phantom. However, dosimeters typically used for this task usually lack in either spatial resolution or dose accuracy. The purpose of this work is to develop and validate a novel type of high resolution 2D dosimeter based on the tomographic reconstruction of the dose projections obtained using long scintillating fibers for the quality assurance of modern radiotherapy techniques such as IMRT. METHODS: Fifty parallel scintillating fibers were aligned in a 30 cm diameter cylindrical masonite phantom with a 95 cm source-to-surface distance and a 100 cm source-to-fibers distance. The fibers were disposed so that the effective detection area of the scintillating fibers was a 20 cm diameter disk. Both ends of each scintillating fiber were coupled to clear optical fibers to enable light collection by a single CCD camera. Seven IMRT segments and two square fields were acquired using 18 projections over a 170° rotation of the device. Computation of the dose integrals was made for each scintillating fiber using the irradiation of known rectangular reference fields. Dose reconstructions were conducted using a total-variation minimization iterative reconstruction algorithm. Eight monitor units were programmed for each projection and the reconstructed dose grid pixel resolution was set to 1 × 1 mm(2). RESULTS: 3%∕3 mm gamma tests conducted between the reconstructed IMRT dose distributions and the dose calculated with the treatment planning system Pinnacle(3) were on average successful for 99.6% of the dose pixels with a predicted dose of at least 10% of the maximum dose. The dose profiles for both square fields and IMRT segments agreed within 2% to the dose calculated with Pinnacle(3) except in high dose gradient regions, and were comparable to the dose measured using an ionization chamber array (IBA MatriXX) and radiographic films (Kodak XV2). CONCLUSIONS: Using tomographic reconstruction on the projections acquired with rotating scintillating fibers, we were able to perform water-equivalent 2D dosimetry of square fields and IMRT segments with acceptable accuracy and high spatial resolution. The underlying concept of tomographic dosimetry and the small number of fibers needed to reconstruct a given 2D dose distribution offer new dosimetric possibilities, both applicable to 2D and 3D dosimetry.

Dosimetric performance and array assessment of plastic scintillation detectors for stereotactic radiosurgery quality assurance.

PURPOSE: To compare the performance of plastic scintillation detectors (PSD) for quality assurance (QA) in stereotactic radiosurgery conditions to a microion-chamber (IC), Gafchromic EBT2 films, 60 008 shielded photon diode (SD) and unshielded diodes (UD), and assess a new 2D crosshair array prototype adapted to small field dosimetry. METHODS: The PSD consists of a 1 mm diameter by 1 mm long scintillating fiber (BCF-60, Saint-Gobain, Inc.) coupled to a polymethyl-methacrylate optical fiber (Eska premier, Mitsubishi Rayon Co., Ltd., Tokyo, Japan). Output factors (S(c,p)) for apertures used in radiosurgery ranging from 4 to 40 mm in diameter have been measured. The PSD crosshair array (PSDCA) is a water equivalent device made up of 49 PSDs contained in a 1.63 cm radius area. Dose profiles measurements were taken for radiosurgery fields using the PSDCA and were compared to other dosimeters. Moreover, a typical stereotactic radiosurgery treatment using four noncoplanar arcs was delivered on a spherical phantom in which UD, IC, or PSD was placed. Using the Xknife planning system (Integra Radionics Burlington, MA), 15 Gy was prescribed at the isocenter, where each detector was positioned. RESULTS: Output Factors measured by the PSD have a mean difference of 1.3% with Gafchromic EBT2 when normalized to a 10 × 10 cm(2) field, and 1.0% when compared with UD measurements normalized to the 35 mm diameter cone. Dose profiles taken with the PSD crosshair array agreed with other single detectors dose profiles in spite of the presence of the 49 PSDs. Gamma values comparing 1D dose profiles obtained with PSD crosshair array with Gafchromic EBT2 and UD measured profiles shows 98.3% and 100.0%, respectively, of detector passing the gamma acceptance criteria of 0.3 mm and 2%. The dose measured by the PSD for a complete stereotactic radiosurgery treatment is comparable to the planned dose corrected for its SD-based S(c,p) within 1.4% and 0.7% for 5 and 35 mm diameter cone, respectively. Furthermore, volume averaging of the IC can be observed for the 5 mm aperture where it differs by as much as 9.1% compared to the PSD measurement. The angular dependency of the UD is also observed, unveiled by an under-response around 2.5% of both 5 and 35 mm apertures. CONCLUSIONS: Output Factors and dose profiles measurements performed, respectively, with the PSD and the PSDCA were in agreement with those obtained with the UD and EBT2 films. For stereotactic radiosurgery treatment verification, the PSD gives accurate results compared to the planning system and the IC once the latter is corrected to compensate for the averaging effect of the IC. The PSD provides precise results when used as a single detector or in a dense array, resulting in a great potential for stereotactic radiosurgery QA measurements.

Spectral method for the correction of the Cerenkov light effect in plastic scintillation detectors: a comparison study of calibration procedures and validation in Cerenkov light-dominated situations.

PURPOSE: The purposes of this work were: (1) To determine if a spectral method can accurately correct the Cerenkov light effect in plastic scintillation detectors (PSDs) for situations where the Cerenkov light is dominant over the scintillation light and (2) to develop a procedural guideline for accurately determining the calibration factors of PSDs. METHODS: The authors demonstrate, by using the equations of the spectral method, that the condition for accurately correcting the effect of Cerenkov light is that the ratio of the two calibration factors must be equal to the ratio of the Cerenkov light measured within the two different spectral regions used for analysis. Based on this proof, the authors propose two new procedures to determine the calibration factors of PSDs, which were designed to respect this condition. A PSD that consists of a cylindrical polystyrene scintillating fiber (1.6 mm3) coupled to a plastic optical fiber was calibrated by using these new procedures and the two reference procedures described in the literature. To validate the extracted calibration factors, relative dose profiles and output factors for a 6 MV photon beam from a medical linac were measured with the PSD and an ionization chamber. Emphasis was placed on situations where the Cerenkov light is dominant over the scintillation light and on situations dissimilar to the calibration conditions. RESULTS: The authors found that the accuracy of the spectral method depends on the procedure used to determine the calibration factors of the PSD and on the attenuation properties of the optical fiber used. The results from the relative dose profile measurements showed that the spectral method can correct the Cerenkov light effect with an accuracy level of 1%. The results obtained also indicate that PSDs measure output factors that are lower than those measured with ionization chambers for square field sizes larger than 25 x 25 cm2, in general agreement with previously published Monte Carlo results. CONCLUSIONS: The authors conclude that the spectral method can be used to accurately correct the Cerenkov light effect in PSDs. The authors confirmed the importance of maximizing the difference of Cerenkov light production between calibration measurements. The authors also found that the attenuation of the optical fiber, which is assumed to be constant in the original formulation of the spectral method, may cause a variation of the calibration factors in some experimental setups.

A new water-equivalent 2D plastic scintillation detectors array for the dosimetry of megavoltage energy photon beams in radiation therapy.

PURPOSE: The objective of this work is to present a new 2D plastic scintillation detectors array (2D-PSDA) designed for the dosimetry of megavoltage (MV) energy photon beams in radiation therapy and to characterize its basic performance. METHODS: We developed a 2D detector array consisting of 781 plastic scintillation detectors (PSDs) inserted into a plane of a water-equivalent phantom. The PSDs were distributed on a 26 × 26 cm(2) grid, with an interdetector spacing of 10 mm, except for two perpendicular lines centered on the detection plane, where the spacing was 5 mm. Each PSD was made of a 1 mm diameter by 3 mm long cylindrical polystyrene scintillating fiber coupled to a clear nonscintillating plastic optical fiber. All of the light signals emitted by the PSDs were read simultaneously with an optical system at a rate of one measurement per second. We characterized the performance of the optical system, the angular dependency of the device, and the perturbation of dose distributions caused by the hundreds of PSDs inserted into the phantom. We also evaluated the capacity of the system to monitor complex multileaf collimator (MLC) sequences such as those encountered in step-and-shoot intensity modulated radiation therapy (IMRT) plans. We compared our results with calculations performed by a treatment planning system and with measurements taken with a 2D ionization chamber array and with a radiochromic film. RESULTS: The detector array that we developed allowed us to measure doses with an average precision of better than 1% for cumulated doses equal to or greater than 6.3 cGy. Our results showed that the dose distributions produced by the 6-MV photon beam are not perturbed (within ±1.1%) by the presence of the hundreds of PSDs located into the phantom. The results also showed that the variations in the beam incidences have little effect on the dose response of the device. For all incidences tested, the passing rates of the gamma tests between the 2D-PSDA and the treatment planning system were higher than 97.5% when the standard clinical tolerances of 3% or 3 mm were used. Excellent agreement was obtained between the doses measured and calculated when we used the 2D-PSDA for monitoring a MLC sequence from a step-and-shoot IMRT plan. CONCLUSIONS: We demonstrated the feasibility of using a large number of PSDs in a new 2D-PSDA for the dosimetry of MV energy photon beams in radiation therapy. The excellent precision, accuracy, and low angular dependence of the device indicate that such a prototype could potentially be used as a high-accuracy quality assurance tool for IMRT and arc therapy patient plan verification. The homogeneity and water-equivalence of the prototype we built suggest that this technology could be extended to multiple detection planes by arranging the fibers into more complex orientations, opening the possibility for 3D dosimetry with PSDs.

Extraction of depth-dependent perturbation factors for parallel-plate chambers in electron beams using a plastic scintillation detector.

PURPOSE: This work presents the experimental extraction of the overall perturbation factor PQ in megavoltage electron beams for NACP-02 and Roos parallel-plate ionization chambers using a plastic scintillation detector (PSD). METHODS: The authors used a single scanning PSD mounted on a high-precision scanning tank to measure depth-dose curves in 6, 12, and 18 MeV clinical electron beams. The authors also measured depth-dose curves using the NACP-02 and PTW Roos chambers. RESULTS: The authors found that the perturbation factors for the NACP-02 and Roos chambers increased substantially with depth, especially for low-energy electron beams. The experimental results were in good agreement with the results of Monte Carlo simulations reported by other investigators. The authors also found that using an effective point of measurement (EPOM) placed inside the air cavity reduced the variation of perturbation factors with depth and that the optimal EPOM appears to be energy dependent. CONCLUSIONS: A PSD can be used to experimentally extract perturbation factors for ionization chambers. The dosimetry protocol recommendations indicating that the point of measurement be placed on the inside face of the front window appear to be incorrect for parallel-plate chambers and result in errors in the R50 of approximately 0.4 mm at 6 MeV, 1.0 mm at 12 MeV, and 1.2 mm at 18 MeV.

A design methodology using signal-to-noise ratio for plastic scintillation detectors design and performance optimization.

PURPOSE: The design of novel plastic scintillation detectors (PSDs) is impeded by the lack of a suitable framework to simulate and predict their performance. The authors propose to use the signal-to-noise ratio (SNR) to model the performance of PSDs that use charge-coupled devices (CCDs) as photodetectors. METHODS: In PSDs using CCDs, the SNR is inversely related to the normalized standard deviation of the dose measurement. Thus, optimizing the SNR directly optimizes the system's precision. In this work, a model of SNR as a function of the system parameters is derived for optical fiber-based PSD systems. Furthermore, this proposed model is validated using experimental results. A formula for the efficiency of fiber coupling to CCDs is derived and used to simulate the performance of a PSD under varying magnifications. RESULTS: The proposed model is shown to simulate the experimental performance of an actual PSD to a suitable degree of accuracy under various conditions. CONCLUSIONS: The SNR constitutes a useful tool to simulate the dosimetric precision of PSDs. Using the SNR model, recommendations for the design and optimization of PSDs are provided. Using the same framework, recommendations for non-fiber-based PSDs are also provided.

Clinical prototype of a plastic water-equivalent scintillating fiber dosimeter array for QA applications.

A clinical prototype of a scintillating fiber dosimeter array for quality assurance applications is presented. The array consists of a linear array of 29 plastic scintillation detectors embedded in a water-equivalent plastic sheet coupled to optical fibers used to guide optical photons to a charge coupled device (CCD) camera. The CCD is packaged in a light-tight, radiation-shielded housing designed for convenient transport. A custom designed connector is used to ensure reproducible mechanical positioning of the optical fibers relative to the CCD. Profile and depth dose characterization measurements are presented and show that the prototype provides excellent dose measurement reproducibility (+/-0.8%) in-field and good accuracy (+/-1.6% maximum deviation) relative to the dose measured with an IC10 ionization chamber.

Surface preparation and coupling in plastic scintillator dosimetry.

One way to improve the performance of scintillation dosimeters is to increase the light-collection efficiency at the coupling interfaces of the detector system. We performed a detailed study of surface preparation of scintillating fibers and their coupling with clear optical fibers to minimize light loss and increase the amount of light collected. We analyzed fiber-surface polishing with aluminum oxide sheets, coating fibers with magnesium oxide, and the use of eight different coupling agents (air, three optical gels, an optical curing agent, ultraviolet light, cyanoacrylate glue, and acetone). We prepared 10 scintillating fiber and clear optical fiber light guide samples to test different coupling methods. To test the coupling, we first cut both the scintillating fiber and the clear optical fiber. Then, we cleaned and polished both ends of both fibers. Finally, we coupled the scintillating fiber with the clear optical fiber in either a polyethylene jacket or a V-grooved support depending on the coupling agent used. To produce more light, we used an ultraviolet lamp to stimulate scintillation. A typical series of similar couplings showed a standard deviation in light-collection efficiency of 10%. This can be explained by differences in the surface preparation quality and alignment of the scintillating fiber with the clear optical fiber. Absence of surface polishing reduced the light collection by approximately 40%, and application of magnesium oxide on the proximal end of the scintillating fiber increased the amount of light collected from the optical fiber by approximately 39%. Of the coupling agents, we obtained the best results using one of the optical gels. Because a large amount of the light produced inside a scintillator is usually lost, better light-collection efficiency will result in improved sensitivity.

Plastic scintillation dosimetry: optimal selection of scintillating fibers and scintillators.

Scintillation dosimetry is a promising avenue for evaluating dose patterns delivered by intensity-modulated radiation therapy plans or for the small fields involved in stereotactic radiosurgery. However, the increase in signal has been the goal for many authors. In this paper, a comparison is made between plastic scintillating fibers and plastic scintillator. The collection of scintillation light was measured experimentally for four commercial models of scintillating fibers (BCF-12, BCF-60, SCSF-78, SCSF-3HF) and two models of plastic scintillators (BC-400, BC-408). The emission spectra of all six scintillators were obtained by using an optical spectrum analyzer and they were compared with theoretical behavior. For scintillation in the blue region, the signal intensity of a singly clad scintillating fiber (BCF-12) was 120% of that of the plastic scintillator (BC-400). For the multiclad fiber (SCSF-78), the signal reached 144% of that of the plastic scintillator. The intensity of the green scintillating fibers was lower than that of the plastic scintillator: 47% for the singly clad fiber (BCF-60) and 77% for the multiclad fiber (SCSF-3HF). The collected light was studied as a function of the scintillator length and radius for a cylindrical probe. We found that symmetric detectors with nearly the same spatial resolution in each direction (2 mm in diameter by 3 mm in length) could be made with a signal equivalent to those of the more commonly used asymmetric scintillators. With augmentation of the signal-to-noise ratio in consideration, this paper presents a series of comparisons that should provide insight into selection of a scintillator type and volume for development of a medical dosimeter.

Performance assessment of a 2D array of plastic scintillation detectors for IMRT quality assurance.

The purposes of this work are to assess the performance of a 2D plastic scintillation detectors array prototype for quality assurance in intensity-modulated radiation therapy (IMRT) and to determine its sensitivity and specificity to positioning errors of one multileaf collimator (MLC) leaf and one MLC leaf bank by applying the principles of signal detection theory. Ten treatment plans (step-and-shoot delivery) and one volumetric modulated arc therapy plan were measured and compared to calculations from two treatment-planning systems (TPSs) and to radiochromic films. The averages gamma passing rates per beam found for the step-and-shoot plans were 95.8% for the criteria (3%, 2 mm), 97.8% for the criteria (4%, 2 mm), and 98.1% for the criteria (3%, 3 mm) when measurements were compared to TPS calculations. The receiver operating characteristic curves for the one leaf errors and one leaf bank errors were determined from simulations (theoretical upper limits) and measurements. This work concludes that arrays of plastic scintillation detectors could be used for IMRT quality assurance in clinics. The use of signal detection theory could improve the quality of dosimetric verifications in radiation therapy by providing optimal discrimination criteria for the detection of different classes of errors.