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1.
Int J Pharm ; 655: 124070, 2024 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-38554740

RESUMEN

The importance of ink rheology to the outcome of 3D printing is well recognized. However, rheological properties of printing inks containing drug nanocrystals have not been widely investigated. Therefore, the objective of this study was to establish a correlation between the composition of nanocrystal printing ink, the ink rheology, and the entire printing process. Indomethacin was used as a model poorly soluble drug to produce nanosuspensions with improved solubility properties through particle size reduction. The nanosuspensions were further developed into semisolid extrusion 3D printing inks with varying nanocrystal and poloxamer 407 concentrations. Nanocrystals were found to affect the rheological properties of the printing inks both by being less self-supporting and having higher yielding resistances. During printing, nozzle blockages occurred. Nevertheless, all inks were found to be printable. Finally, the rheological properties of the inks were successfully correlated with various printing and product properties. Overall, these experiments shed new light on the rheological properties of printing inks containing nanocrystals.


Asunto(s)
Nanopartículas , Poloxámero , Geles , Excipientes/química , Impresión Tridimensional , Reología , Tinta
2.
Int J Pharm ; 660: 124354, 2024 Jul 20.
Artículo en Inglés | MEDLINE | ID: mdl-38897486

RESUMEN

During recent years there have been shortages of certain drugs due to problems in raw material supply. These are often related to active ingredients but could also affect excipients. Lactose is one of the most used excipients in tableting and comes in two anomeric and several solid-state forms. The aim of this study was to utilize lactose from a dairy side-stream and compare it against a commercial reference in direct compression. This would be a sustainable option and would secure domestic availability during crises. Two types of lactose, spray-dried and freeze-dried, were evaluated. Lactose was mixed with microcrystalline cellulose in different ratios together with lubricant and glidant, and flowability and tabletability of the formulations was characterized. The fully amorphous and small particle-sized spray-dried lactose flowed inadequately but exhibited good tabletability. The larger particle-sized, freeze-dried lactose exhibited sufficient flow and better tabletability than the commercial reference. However, disintegration and drug release were slower when using the investigational lactose formulations. This was most likely due to remaining milk proteins, especially caseins, in the lactose. Overall, the investigational lactose provides promise for the use of such a side-stream product during crisis situations but enhancing their properties and/or purity would be needed.


Asunto(s)
Celulosa , Composición de Medicamentos , Liberación de Fármacos , Excipientes , Liofilización , Lactosa , Comprimidos , Lactosa/química , Excipientes/química , Celulosa/química , Composición de Medicamentos/métodos , Prueba de Estudio Conceptual , Tamaño de la Partícula , Secado por Pulverización , Industria Lechera , Química Farmacéutica/métodos
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