RESUMEN
Supramolecular chemistry combines the strength of molecular assembly via various molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of directionality, specificity, reversibility, and strength is a promising approach for constructing advanced supramolecules. There are still some challenges in hydrogen bonding based supramolecular polymers, such as complexity originating from tautomerism of the molecular building modules, the assembly process, and structure versatility of building blocks. In this review, examples are selected to give insights into multiple hydrogen bonding driven emerging supramolecular architectures. We focus on chiral supramolecular assemblies, multiple hydrogen bonding modules as stimuli responsive sources, interpenetrating polymer networks, multiple hydrogen bonding assisted organic frameworks, supramolecular adhesives, energy dissipators, and quantitative analysis of nano-adhesion. The applications in biomedical materials are focused with detailed examples including drug design evolution for myotonic dystrophy, molecular assembly for advanced drug delivery, an indicator displacement strategy for DNA detection, tissue engineering, and self-assembly complexes as gene delivery vectors for gene transfection. In addition, insights into the current challenges and future perspectives of this field to propel the development of multiple hydrogen bonding facilitated supramolecular materials are proposed.
Asunto(s)
Materiales Biocompatibles , Polímeros , Enlace de Hidrógeno , Polímeros/químicaRESUMEN
Lipid nanoparticles (LNPs)-based messenger RNA (mRNA) therapeutics have emerged with promising potentials in the fields of infectious diseases, cancer vaccines, and protein replacement therapies; however, their therapeutic efficacy and safety can still be promoted by the optimization of LNPs formulations. Unfortunately, current LNPs suffer from increased production of reactive oxygen species during translation, which leads to a decreased translation efficiency and the onset of inflammation and other side effects. Herein, we synthesize a lipid-modified poly(guanidine thioctic acid) polymer to fabricate novel LNPs for mRNA vaccines. The acquired G-LNPs significantly promote the translation efficiency of loaded mRNA and attenuate inflammation after vaccination through the elimination of reactive oxygen species that are responsible for translational inhibition and inflammatory responses. In vivo studies demonstrate the excellent antitumor efficacy of the G-LNPs@mRNA vaccine, and two-dose vaccination dramatically increases the population and infiltration of cytotoxic T cells due to the intense antitumor immune responses, thus generating superior antitumor outcomes compared with the mRNA vaccine prepared from traditional LNPs. By synergy with immune checkpoint blockade, the tumor inhibition of G-LNPs@mRNA is further boosted, indicating that G-LNPs-based mRNA vaccines will be powerful and versatile platforms to combat cancer.
Asunto(s)
Vacunas contra el Cáncer , Lípidos , Liposomas , Nanopartículas , ARN Mensajero , Vacunas contra el Cáncer/química , Vacunas contra el Cáncer/inmunología , Nanopartículas/química , Animales , Ratones , ARN Mensajero/genética , ARN Mensajero/inmunología , Lípidos/química , Humanos , Ácido Tióctico/química , Ácido Tióctico/farmacología , Polímeros/química , Guanidinas/química , Guanidinas/farmacología , Línea Celular TumoralRESUMEN
Supramolecular polymers, generated by connecting monomers through noncovalent interactions, have received considerable attention over the past years, as they provide versatile platforms for developing diverse aesthetically pleasing polymeric structures with promising applications in a variety of fields, such as medicine, catalysis, and sensing. In the development of supramolecular polymers, macrocyclic hosts play a very important role. Benefiting from their abundant host-guest chemistry and self-assembly characteristics, macrocycles themselves or their host-guest complexes can self-assemble to form well-ordered supramolecular polymeric architectures including pseudopolyrotaxanes and polyrotaxanes. The integration of these topological structures into supramolecular polymeric materials also imbues them with some unforeseen functions. Current interest in macrocycle-based supramolecular polymers is mostly focused on the development of supramolecular soft materials in solution or gel-state, in which the dynamic nature of noncovalent interactions endows supramolecular polymers with a wealth of "smart" properties, such as multiresponsiveness and self-repair capabilities. While preparation of macrocycle-derived supramolecular polymers in the solid state is a relatively challenging but intriguing prospect, they are an important part of the field of supramolecular polymers. On one hand, the construction of macrocycle-based solid-state supramolecular polymers enables us to obtain new materials with novel properties and functions such as mechano-responsiveness. On the other hand, the molecular structures and arrangements in these materials are well-identified by X-ray crystallography techniques, offering a direct visual representation of the supramolecular polymerization process. The analysis of the role of noncovalent interactions in these architectures allows us to design more sophisticated and elegant supramolecular polymers in a highly rationalized and controllable manner. This Account serves to summarize the research progress on macrocycle-based solid-state supramolecular polymers (MSSPs), including the contributions toward this field made by our group. For constructing MSSPs, the key point is to control noncovalent interactions. Thus, in this Account, we primarily classify these MSSPs by different noncovalent interactions involved to connect the monomers, including metal-ligand interactions, host-guest interactions, π···π stacking, and halogen bonding. These noncovalent interactions are highly associated with the structures and functions of the resultant MSSPs. For instance, using metal-ligand interactions as driving forces, metal clusters can be introduced in MSSPs which afford systems with solid-state luminescence or proton conduction properties; supramolecular polymerization using macrocycle-based host-guest interactions can modulate the molecular arrangement of some specific molecules in the solid state, which further influences their solid-state properties; π···π stacking interactions and halogen bonding give chemists more choice to design MSSPs with various elements. The role of macrocyclic hosts in MSSPs is also revealed in these descriptions. Finally, the remaining challenges are identified for further development of future prospects. We hope that this Account can inspire new discoveries in the realm of supramolecular functional systems and offer new opportunities for the construction of supramolecular architectures and solid-state materials.
Asunto(s)
Polímeros , Sustancias Macromoleculares/química , Conformación Molecular , Estructura Molecular , Polimerizacion , Polímeros/químicaRESUMEN
The nature of mechanically interlocked molecules (MIMs) has continued to encourage researchers to design and construct a variety of high-performance materials. Introducing mechanically interlocked structures into polymers has led to novel polymeric materials, called mechanically interlocked polymers (MIPs). Rotaxane-based MIPs are an important class, where the mechanically interlocked characteristic retains a high degree of structural freedom and mobility of their components, such as the rotation and sliding motions of rotaxane units. Therefore, these MIP materials are known to possess a unique set of properties, including mechanical robustness, adaptability and responsiveness, which endow them with potential applications in many emerging fields, such as protective materials, intelligent actuators, and mechanisorption. In this review, we outline the synthetic strategies, structure-property relationships, and application explorations of various polyrotaxanes, including linear polyrotaxanes, polyrotaxane networks, and rotaxane dendrimers.
Asunto(s)
Rotaxanos , Polímeros , Rotaxanos/químicaRESUMEN
Among the many challenges in medicine, the treatment and cure of cancer remains an outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the integration of therapy and diagnosis in nanoformulations, is the next generation of personalized medicine to meet the challenges in precise cancer diagnosis, rational management and effective therapy, aiming to significantly increase the survival rate and improve the life quality of cancer patients. Different from most conventional platforms with unsatisfactory theranostic capabilities, supramolecular cancer nanotheranostics have unparalleled advantages in early-stage diagnosis and personal therapy, showing promising potential in clinical translations and applications. In this review, we summarize the progress of supramolecular cancer nanotheranostics and provide guidance for designing new targeted supramolecular theranostic agents. Based on extensive state-of-the-art research, our review will provide the existing and new researchers a foundation from which to advance supramolecular cancer nanotheranostics and promote translationally clinical applications.
Asunto(s)
Antineoplásicos/química , Nanoestructuras/química , Neoplasias/diagnóstico , Neoplasias/terapia , Medicina de Precisión/métodos , Nanomedicina Teranóstica/métodos , Animales , Antineoplásicos/farmacología , Transporte Biológico , ADN/química , Humanos , Liposomas/química , Nucleótidos/química , Compuestos Organometálicos/química , Proteínas/químicaRESUMEN
Liposomes and polymersomes, typical vesicular drug delivery systems (DDSs), have faced some limitations in cancer theranostics. Suprasomes, supramolecular vesicles assembled from amphiphiles linked by noncovalent interactions, show potential as new generation of vesicular DDSs. We construct suprasomes based on host-guest recognition, by which the desired functions can be integrated into carriers without tedious synthesis. Photothermally active host-guest complex is formed between a functional guest and pillar[5]arene, which further self-assembles into hollow suprasomes. A supramolecular nanomedicine is developed by encapsulating cisplatin in the suprasomes. The obtained cisplatin@Suprasomes achieve excellent anticancer efficacy and anti-metastasis combining chemotherapy and photothermal therapy, which ablate the tumors without relapse and metastasis. This work demonstrates the facile functionalization of suprasomes, holding promise as alternatives to liposomes and polymersomes.
Asunto(s)
Liposomas , Neoplasias , Humanos , Medicina de Precisión , Cisplatino , Sistemas de Liberación de Medicamentos , Neoplasias/diagnóstico por imagen , Neoplasias/tratamiento farmacológicoRESUMEN
Supramolecular nanomedicines have shown great merits in cancer therapy, but their clinical translation is hampered by monotonous therapeutic modality and unsatisfactory antitumor performance. Herein, a hybrid supramolecular polymeric nanomedicine (SNPs) is developed based on ß-cyclodextrin/camptothecin (CPT) host-guest molecular recognition and iron-carboxylate coordination. Iron ions stabilizing SNPs catalyze the conversion of intracellular hydrogen peroxide into highly toxic hydroxyl radical through a Fenton reaction, which further cleaves the thioketal linker of the supramolecular monomer to release potent CPT, thus amplifying the therapeutic efficacy by combining chemodynamic therapy and chemotherapy. The combination therapy stimulates antitumor immunity and promotes intratumoral infiltration of cytotoxic T lymphocytes by triggering immunogenic cell death. In synergy with PD-L1 checkpoint blockade, SNPs enables enhanced immune therapy and a long-term tumor remission.
Asunto(s)
Nanopartículas , Neoplasias , Camptotecina/farmacología , Camptotecina/uso terapéutico , Línea Celular Tumoral , Humanos , Hierro/uso terapéutico , Nanomedicina , Nanopartículas/uso terapéutico , Neoplasias/tratamiento farmacológico , Polímeros/uso terapéutico , beta-Ciclodextrinas/farmacología , beta-Ciclodextrinas/uso terapéuticoRESUMEN
The recent progress in platinum(II) coordination-driven supramolecular polymers has had a substantial effect on the design of functional soft materials. However, the prospect of realizing polymerization induced by platinum(II) metallacycle-based host-guest interactions has received little attention until recently. Here we report the realization of supramolecular polymerization driven by platinum(II) metallacycle-based host-guest interactions both in the solid state and in solution. On the basis of the disclosed polymerization mechanism, we present a new strategy for the preparation of platinum(II) metallacycle-based supramolecular polymers.
Asunto(s)
Complejos de Coordinación/química , Platino (Metal)/química , Polímeros/química , Modelos Moleculares , Conformación Molecular , SolucionesRESUMEN
A new strategy is introduced to prepare an adaptive polymer gel that has a unique adaptability in response to environmental stimuli. This gel is prepared by the thiol-ene "click" reaction between a bisvinyl [2]catenane and a poly(ethylene glycol) derivative containing multiple thiol groups. The catenane crosslinker is responsive to external stimuli due to the existence of intercomponent hydrogen bonding (IHB). The strong IHB restricts the rotation and movement of the crosslinker, giving it a rigid feature; however, the crosslinker becomes flexible when the IHB is destroyed. In consequence, the resulting gel can be reversibly switched between tough and soft states under stimulations.
Asunto(s)
Antracenos/química , Reactivos de Enlaces Cruzados/química , Polietilenglicoles/química , Geles/química , Enlace de Hidrógeno , Estructura Molecular , Compuestos de Sulfhidrilo/químicaRESUMEN
In this work, a Pd2 L4 metallacage 2â¢([BF4 ]- )4 with four pillar[5]arene units is first prepared and characterized by 1D multinuclear NMR (1 H, 11 B, and 19 F NMR), 2D 1 H-1 H correlation spectra, 1 H-13 C heteronuclear single quantum coherence, and diffusion-ordered NMR spectroscopy, and electrospray ionization time-of-flight mass spectrometry. By the introduction of a ditopic guest molecule 3 into a chloroform solution of 2â¢([BF4 ]- )4 , a supramolecular polymer network gel is successfully constructed based on the metal coordination interactions and host-guest recognition between the pillar[5]arene units of 2â¢([BF4 ]- )4 and neutral ditopic guest molecule 3. The temperature and pH responsivenesses of the supramolecular gel are studied, which are further employed for the controlled release of different cargos. As a demonstration, emodin and methylene blue are trapped in the cavities of the metallacage and in the pores of the supramolecular gel, respectively. Methylene blue is first released along with the gel-sol transition while emodin is then released by the further addition of acid to destroy the metallacage. This study explores the use of metallacage-cored supramolecular network gels for sequential controlled release and contributes to the development of smart and adaptive materials.
Asunto(s)
Geles/química , Metales/química , Polímeros/química , Estructura Molecular , TemperaturaRESUMEN
Despite the well-known anticancer activity of mono- and multinuclear platinum complexes, studies of the antitumor performances of platinum-based supramolecular coordination complexes are rare. Herein, we report on the synthesis of a four-armed amphiphilic copolymer, Pt-PAZMB-b-POEGMA, containing a metallacycle M, in which the tetraphenylethene derivative acts as an aggregation-induced emissive fluorescent probe for live cell imaging and the 3,6-bis[trans-Pt(PEt3)2]phenanthrene (PhenPt) is an anticancer drug. This copolymer was further self-assembled into nanoparticles of different sizes and vesicles depending upon the experimental conditions. The impacts of the morphology and size of the assemblies on their endocytic pathways, uptake rates, internalization amounts, and cytotoxicities were investigated. The self-assemblies were further employed to encapsulate doxorubicin (DOX) to achieve a synergistic anticancer effect. Controlled drug release was also realized via amphiphilicity changes and was driven by a glutathione-induced cascade elimination reaction. The DOX-loaded nanoparticles of around 50 nm in size exhibited an excellent antitumor performance as well as a low systemic toxicity, due to an enhanced permeability and retention effect.
Asunto(s)
Antineoplásicos/farmacología , Colorantes Fluorescentes/química , Polímeros/química , Polímeros/farmacología , Animales , Antineoplásicos/administración & dosificación , Antineoplásicos/efectos adversos , Antineoplásicos/química , Supervivencia Celular/efectos de los fármacos , Doxorrubicina/administración & dosificación , Doxorrubicina/efectos adversos , Doxorrubicina/química , Doxorrubicina/farmacología , Portadores de Fármacos/administración & dosificación , Portadores de Fármacos/efectos adversos , Portadores de Fármacos/química , Liberación de Fármacos , Sinergismo Farmacológico , Endocitosis , Glutatión , Células HeLa , Humanos , Ratones , Nanopartículas/administración & dosificación , Nanopartículas/efectos adversos , Nanopartículas/química , Polímeros/administración & dosificación , Polímeros/efectos adversos , Ensayos Antitumor por Modelo de XenoinjertoRESUMEN
Herein, for rate-tunable controlled release, the authors report a new facile method to prepare multiresponsive amphiphilic supramolecular diblock copolymers via the cooperative complexation between a water-soluble pillar[10]arene and paraquat-containing polymers in water. This supramolecular diblock copolymer can self-assemble into multiresponsive polymeric micelles at room temperature in water. The resultant micelles can be further used in the controlled release of small molecules with tunable release rates depending on the type of single stimulus and the combination of various stimuli.
Asunto(s)
Paraquat/química , Polímeros/síntesis química , Rotaxanos/química , Tensoactivos/síntesis química , Sustancias Macromoleculares/síntesis química , Sustancias Macromoleculares/química , Estructura Molecular , Tamaño de la Partícula , Polímeros/química , Propiedades de Superficie , Tensoactivos/químicaRESUMEN
Control over structural transformations in supramolecular entities by external stimuli is critical for the development of adaptable and functional soft materials. Herein, we have designed and synthesized a dipyridyl donor containing a central Z-configured stiff-stilbene unit that self-assembles in the presence of two 180° di-Pt(II) acceptors to produce size-controllable discrete organoplatinum(II) metallacycles with high efficiency by means of the directional-bonding approach. These discrete metallacycles undergo transformation into extended metallosupramolecular polymers upon the conformational switching of the dipyridyl ligand from Z-configured (0°) to E-configured (180°) when photoirradiated. This transformation is accompanied by interesting morphological changes at nanoscopic length scales. The discrete metallacycles aggregate to spherical nanoparticles that evolve into long nanofibers upon polymer formation. These fibers can be reversibly converted to cyclic oligomers by changing the wavelength of irradiation, which reintroduces Z-configured building blocks owing to the reversible nature of stiff-stilbene photoisomerization. The design strategy defined here represents a novel self-assembly pathway to deliver advanced supramolecular assemblies by means of photocontrol.
Asunto(s)
Metales/química , Polímeros/química , Estilbenos/química , Biomimética , Ligandos , Luz , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Ensayo de Materiales , Microscopía Electrónica de Transmisión , Procesos Fotoquímicos , Fotones , Solventes/química , TemperaturaRESUMEN
Herein, first we report the preparation of a thermoresponsive [3]pseudorotaxane from cooperative complexation between a water-soluble pillar[10]arene and a paraquat derivative in water. Then we successfully construct the first pillararene-based gemini-type supra-amphiphilic [3]pseudorotaxane from the water-soluble pillar[10]arene and a paraquat-containing poly(N-isopropylacrylamide) based on this new molecular recognition motif in water. This macromolecular [3]pseudorotaxane shows unique dual-thermoresponsiveness. Furthermore, it can self-assemble into polymeric vesicles at 37 °C in water. These vesicles can be further used in the controlled release of small molecules induced by cooling to 25 °C or heating to 60 °C.
Asunto(s)
Sustancias Macromoleculares/química , Paraquat/química , Rotaxanos/química , Tensoactivos/química , Resinas Acrílicas/química , Complejos de Coordinación/síntesis química , Complejos de Coordinación/química , Interacciones Hidrofóbicas e Hidrofílicas , Sustancias Macromoleculares/síntesis química , Rotaxanos/síntesis química , Tensoactivos/síntesis química , TemperaturaRESUMEN
Macromolecular supra-amphiphiles refer to a kind of macromolecular amphiphiles whose hydrophlic and hydrophobic parts are connected by noncovalent forces. They have applications in various fields, such as drug delivery, sensor systems, and biomedical materials. Here we report a novel molecular recognition motif between a new thermoresponsive water-soluble pillar[7]arene (WP7) and an azobenzene derivative. Furthermore, we utilized this recognition motif to construct the first pillararene-based supra-amphiphilic polypseudorotaxane which can self-assemble to form vesicles in water. Due to the dual-responsiveness of the molecular recognition motif (the thermoresponsiveness of WP7 and photoresponsiveness of azobenzene), the reversible transformations between solid nanospheres based on the self-assembly of the polymer backbone and vesicles based on the self-assembly of the supra-amphiphilic polypseudorotaxane were achieved by adjusting the solution temperature or UV-visible light irradiation. These dual-responsive aggregation behaviors were further used in the controlled release of water-soluble dye calcein molecules.
Asunto(s)
Compuestos Azo/química , Preparaciones de Acción Retardada/química , Polímeros/química , Compuestos de Amonio Cuaternario/química , Rotaxanos/química , Tensoactivos/química , Compuestos Azo/síntesis química , Preparaciones de Acción Retardada/síntesis química , Modelos Moleculares , Polímeros/síntesis química , Compuestos de Amonio Cuaternario/síntesis química , Rotaxanos/síntesis química , Solubilidad , Tensoactivos/síntesis química , Temperatura , Agua/químicaRESUMEN
An emerging strategy for the fabrication of advanced supramolecular materials is the use of hierarchical self-assembly techniques wherein multiple orthogonal interactions between molecular precursors can produce new species with attractive properties. Herein, we unify the spontaneous formation of metal-ligand bonds with the host/guest chemistry of crown ethers to deliver a 3D supramolecular polymer network (SPN). Specifically, we have prepared a highly directional dipyridyl donor decorated with a benzo-21-crown-7 moiety that undergoes coordination-driven self-assembly with a complementary organoplatinum acceptor to furnish hexagonal metallacycles. These hexagons subsequently polymerize into a supramolecular network upon the addition of a bisammonium salt due to the formation of [2]pseudorotaxane linkages between the crown ether and ammonium moieties. At high concentrations, the resulting 3D SPN becomes a gel comprising many cross-linked metallohexagons. Notably, thermo- and cation-induced gel-sol transitions are found to be completely reversible, reflecting the dynamic and tunable nature of such supramolecular materials. As such, these results demonstrate the structural complexity that can be obtained when carefully controlling multiple interactions in a hierarchical fashion, in this case coordination and host/guest chemistry, and the interesting dynamic properties associated with the materials thus obtained.
Asunto(s)
Metales/química , Polímeros/química , Geles , Modelos Moleculares , Conformación MolecularRESUMEN
Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all tumor immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death that is accompanied by immune checkpoint inhibitors, can induce effective immunogenic cell death and long-term immune activation. Therapeutic strategies to jointly induce pyroptosis and reverse immunosuppressive tumor microenvironments are promising for cancer immunotherapy. In this regard, a dual-responsive supramolecular polymeric nanomedicine (NCSNPs) to self-cascade amplify the benefits of cancer immunotherapy is designed. The NCSNPs are formulated by ß-cyclodextrin coupling nitric oxide (NO) donor, a pyroptosis activator, and NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor, and self-assembled through host-guest molecular recognition and hydrophobic interaction to obtain nanoparticles. NCSNPs possess excellent tumor accumulation and bioavailability attributed to ingenious supramolecular engineering. The study not only confirms the occurrence of NO-triggered pyroptosis in tumors for the first time but also reverses the immunosuppressive microenvironment in tumor sites via an IDO inhibitor by enhancing the infiltration of cytotoxic T lymphocytes, to achieve remarkable inhibition of tumor proliferation. Thus, this study provides a novel strategy for cancer immunotherapy.
Asunto(s)
Inmunoterapia , Nanomedicina , Polímeros , Microambiente Tumoral , Inmunoterapia/métodos , Ratones , Animales , Nanomedicina/métodos , Microambiente Tumoral/efectos de los fármacos , Microambiente Tumoral/inmunología , Polímeros/química , Piroptosis/efectos de los fármacos , Nanopartículas/química , Modelos Animales de Enfermedad , Neoplasias/terapia , Neoplasias/inmunología , beta-Ciclodextrinas/química , Humanos , Indolamina-Pirrol 2,3,-Dioxigenasa/antagonistas & inhibidores , Óxido Nítrico/metabolismo , Imidazoles , IsoindolesRESUMEN
A supramolecular cross-linked network was fabricated and demonstrated to act as a multiple fluorescent sensor. It was constructed from a fluorescent conjugated polymer and a bisammonium salt cross-linker driven by dibenzo[24]crown-8/secondary ammonium salt host-guest interactions. Compared with the conjugated polymer, the network has weak fluorescence due to the aggregation of polymer chains. Thanks to the multiple stimuli-responsiveness of host-guest interactions, the fluorescence intensity of the system can be enhanced by four types of signals, including potassium cation, chloride anion, pH increase, and heating. Hence, the network can serve as a cation sensor, an anion sensor, a pH sensor, and a temperature sensor. It can be used in both solution and thin film. Interestingly, exposure of a film made from this supramolecular cross-linked network to ammonia leads to an increase of fluorescence, making it a good candidate for gas detection.
Asunto(s)
Reactivos de Enlaces Cruzados/química , Fluorescencia , Colorantes Fluorescentes/química , Polímeros/química , Reactivos de Enlaces Cruzados/síntesis química , Éteres Corona/química , Colorantes Fluorescentes/síntesis química , Concentración de Iones de Hidrógeno , Sustancias Macromoleculares/síntesis química , Sustancias Macromoleculares/química , Compuestos de Amonio Cuaternario/química , Espectrometría de Fluorescencia , TemperaturaRESUMEN
All the previously reported supramolecular polymers based on crown ether-based molecular recognition have been prepared in anhydrous organic solvents. This is mainly due to the weakness of crown ether-based molecular recognition in the presence of water. Here we report a linear supramolecular polymer constructed from a heteroditopic monomer in an aqueous medium driven by crown ether-based molecular recognition through the introduction of electrostatic attraction. In addition, the reversible transition between the linear supramolecular polymer and oligomers is achieved by adding acid and base. This study realizes the breakthrough of the solvent for supramolecular polymerization driven by crown ether-based molecular recognition from anhydrous organic solvents to aqueous media. It is helpful for achieving supramolecular polymerization driven by crown ether-based molecular recognition in a completely aqueous medium.
Asunto(s)
Éteres Corona/química , Polímeros/síntesis química , Concentración de Iones de Hidrógeno , Estructura Molecular , Polimerizacion , Polímeros/química , Solventes/química , Electricidad EstáticaRESUMEN
Automatic repair: a polymer with pendent dibenzo[24]crown-8 units (purple in picture) was cross-linked by two bisammonium salts (green) to form two supramolecular gels based on host-guest interactions. These two gels are stimuli-responsive materials that respond to changes of the pH value and are also self-healing materials, as can be seen by eye and as evidenced by rheological data.